Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.63 |
| ▸ | GAA | P10253 | 7/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16566653 | 0.92 | CYP1A2 (0.57) | MAPTGAASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL21626767 | 0.87 | CYP1A2 (0.53) | MAPTGAASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL13875562 | 0.83 | GAA (0.69) | MAPTGAASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL30389995 | 0.83 | NOX1 (0.67) | MAPTGAASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL21626718 | 0.81 | MAPT (0.73) | MAPTGAASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL11231477 | 0.81 | RAB9A (0.67) | MAPTGAASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL14832809 | 0.81 | RAB9A (0.67) | MAPTGAASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL15711083 | 0.80 | GAA (0.55) | MAPTGAASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL15711084 | 0.80 | GAA (0.55) | MAPTGAASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL28937334 | 0.80 | MAPT (0.58) | MAPTGAASMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071782-B2 | Synthesis of 1,3,4-trisubstituted and 1,3,4,5-tetrasubstituted pyrazoles | JANSSEN PHARMACEUTICA NV (BE) | 2011-12-06 | — | — | US | disclosed |
| US-8071782-B2 | Synthesis of 1,3,4-trisubstituted and 1,3,4,5-tetrasubstituted pyrazoles | JANSSEN PHARMACEUTICA NV (BE) | 2011-12-06 | — | — | US | disclosed |
| US-20090093637-A1 | Synthesis of 1,3,4-Trisubstituted and 1,3,4,5-Tetrasubstituted Pyrazoles | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-09 | — | — | US | disclosed |
| US-20090093637-A1 | Synthesis of 1,3,4-Trisubstituted and 1,3,4,5-Tetrasubstituted Pyrazoles | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093637-A1 | Synthesis of 1,3,4-Trisubstituted and 1,3,4,5-Tetrasubstituted Pyrazoles | CYP3A4, CYP4B1, CYP2E1 | MAPT 1343/4885GAA 4410/4885SMN1; SMN2 4224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.