SCHEMBL1387660

SCHEMBL1387660

CCCC[C@@]1(CC)CSc2cc(OC)ccc2[C@H](c2ccccc2)N1

nearest known ligand 0.52

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SLC10A2 Q12908 20/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7465173 1.00 SLC10A2 (0.52) SLC10A2
SCHEMBL1387661 1.00 SLC10A2 (0.52) SLC10A2
SCHEMBL8380396 0.92 SLC10A2 (0.52) SLC10A2
SCHEMBL8239487 0.92 SLC10A2 (0.52) SLC10A2
SCHEMBL8239482 0.92 SLC10A2 (0.52) SLC10A2
SCHEMBL8380393 0.92 SLC10A2 (0.52) SLC10A2
SCHEMBL8200621 0.92 SLC10A2 (0.52) SLC10A2
SCHEMBL8194080 0.91 SLC10A2 (0.42) SLC10A2
SCHEMBL8223063 0.91 SLC10A2 (0.47) SLC10A2
SCHEMBL22347035 0.91 SLC10A2 (0.47) SLC10A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-H10504035-A 1998-04-14 JP claimed
EP-0775126-A1 HYPOLIPIDEMIC 1,4-BENZOTHIAZEPINE-1,1-DIOXIDES THE WELLCOME FOUNDATION LIMITED (GB) 1997-05-28 EP claimed
WO-1996005188-A1 HYPOLIPIDEMIC 1,4-BENZOTHIAZEPINE-1,1-DIOXIDES THE WELLCOME FOUNDATION LIMITED (GB) 1996-02-22 WO claimed
EP-2968262-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF BARRETT'S ESOPHAGUS AND GASTROESOPHAGEAL REFLUX DISEASE Lumena Pharmaceuticals, Inc. (US) 2016-01-20 EP disclosed
EP-2968230-A2 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF PRIMARY SCLEROSING CHOLANGITIS AND INFLAMMATORY BOWEL DISEASE Lumena Pharmaceuticals, Inc. (US) 2016-01-20 EP disclosed
WO-2015065983-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF GASTROINTESTINAL INFECTIONS Lumena Pharmaceuticals, Inc. (US) 2015-05-07 WO disclosed
WO-2014144485-A9 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF BARRETT'S ESOPHAGUS AND GASTROESOPHAGEAL REFLUX DISEASE Lumena Pharmaceuticals, Inc. (US) 2015-01-15 WO disclosed
WO-2014144650-A2 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF PRIMARY SCLEROSING CHOLANGITIS AND INFLAMMATORY BOWEL DISEASE Lumena Pharmaceuticals, Inc. (US) 2014-09-18 WO disclosed
WO-2014144485-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF BARRETT'S ESOPHAGUS AND GASTROESOPHAGEAL REFLUX DISEASE Lumena Pharmaceuticals, Inc. (US) 2014-09-18 WO disclosed
EP-2770990-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF HYPERCHOLEMIA AND CHOLESTATIC LIVER DISEASE Lumena Pharmaceuticals, Inc. (US) 2014-09-03 EP disclosed
EP-2771003-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF PEDIATRIC CHOLESTATIC LIVER DISEASES Lumena Pharmaceuticals, Inc. (US) 2014-09-03 EP disclosed
WO-2013063512-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF PEDIATRIC CHOLESTATIC LIVER DISEASES LUMENA PHARMACEUTICALS, INC (US) 2013-05-02 WO disclosed
EP-2575821-A2 BILE ACID RECYCLING INHIBITORS AND SATIOGENS FOR TREATMENT OF DIABETES, OBESITY, AND INFLAMMATORY GASTROINTESTINAL CONDITIONS Satiogen Pharmaceuticals, Inc. (US) 2013-04-10 EP disclosed
WO-2013020108-A2 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF PANCREATITIS Lumena Pharmaceuticals, Inc. (US) 2013-02-07 WO disclosed
WO-2011150286-A2 BILE ACID RECYCLING INHIBITORS AND SATIOGENS FOR TREATMENT OF DIABETES, OBESITY, AND INFLAMMATORY GASTROINTESTINAL CONDITIONS SATIOGEN PHARMACEUTICALS,INC. (US) 2011-12-01 WO disclosed
EP-0775126-B1 HYPOLIPIDEMIC 1,4-BENZOTHIAZEPINE-1,1-DIOXIDES WELLCOME FOUND (GB) 2002-10-30 EP disclosed
EP-1203769-A1 Hypolipidemic 1,4-benzothiazepine derivative THE WELLCOME FOUNDATION LIMITED (GB) 2002-05-08 EP disclosed
US-5910494-A NOVEL COMPOUNDS THAT REDUCE THE ABSORPTION OF BILE ACIDS FROM THE INTESTINE; FOR PROPHYLAXIS AND TREATMENT OF HYPERLIPIDEMIC CONDITIONS, SUCH AS ATHEROSCLEROSIS GLAXO WELLCOME INC. (US) 1999-06-08 US disclosed
EP-0775126-A1 HYPOLIPIDEMIC 1,4-BENZOTHIAZEPINE-1,1-DIOXIDES THE WELLCOME FOUNDATION LIMITED (GB) 1997-05-28 EP disclosed
WO-1996005188-A1 HYPOLIPIDEMIC 1,4-BENZOTHIAZEPINE-1,1-DIOXIDES THE WELLCOME FOUNDATION LIMITED (GB) 1996-02-22 WO disclosed