SLC10A2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL347340	1.00	20/20
SCHEMBL349299	1.00	20/20
SCHEMBL349300	1.00	20/20
SCHEMBL348804	0.76	20/20
Hydrochloric Acid (SCHEMBL349001)	0.74	20/20
SCHEMBL347952	0.67	20/20
SCHEMBL349650	0.67	20/20
SCHEMBL366859	0.67	20/20
SCHEMBL347797	0.65	20/20
SCHEMBL348624	0.65	20/20
SCHEMBL348841	0.64	20/20
Bromide (SCHEMBL347142)	0.63	20/20
SCHEMBL349686	0.63	20/20
SCHEMBL348852	0.62	20/20
SCHEMBL919677	0.62	20/20
SCHEMBL347586	0.61	20/20
SCHEMBL919249	0.61	20/20
Bromide (SCHEMBL349464)	0.59	20/20
SCHEMBL366691	0.59	20/20
SCHEMBL920147	0.59	20/20

Clinical trials — most relevant to SLC10A2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Treatment of Bile Acid Diarrhoea With Atorvastatin	PHASE4	RECRUITING
SGLT-2 Inhibitor Empagliflozin Effects on Appetite and Weight Regulation.	PHASE4	COMPLETED
Obeticholic Acid Among Chronic HBV Patients with Hepatic Steatosis : Clinical and Portal Doppler Outcomes	PHASE3	NOT_YET_RECRUITING
BSEP Function Rescue During Childhood Inhereditary Cholestatic Diseases	PHASE2/PHASE3	WITHDRAWN
Dose Response Study of GSK2330672 for the Treatment of Pruritus in Participants With Primary Biliary Cholangitis	PHASE2	COMPLETED
Secretin in Ex-situ Liver Perfusion	PHASE1/PHASE2	ENROLLING_BY_INVITATION
Does Welchol (Colesevelam Hydrochloride) Improve Colonic Transit in Diarrhea-predominant Irritable Bowel Syndrome (D-IBS)?	PHASE2	COMPLETED
Cheno Effect on Transit in Health and IBS-C	PHASE2	COMPLETED
Efficacy and Tolerability of Tauroursodeoxycholic Acid in Amyotrophic Lateral Sclerosis	PHASE2	COMPLETED
Obeticholic Acid in Bile Acid Diarrhoea	PHASE2	COMPLETED
Evaluating Safe Ketone Thresholds To Minimise Ketosis in People With Type 1 Diabetes Using Dapagliflozin	PHASE2	NOT_YET_RECRUITING
Bioavailability of Paracetamol, Amoxicillin and Talinolol Before, Immediately and One Year After Gastric Bypass Operation	PHASE1	COMPLETED
Effect of Metformin on Gut Peptides , Bile Acids and Lipid Profiles in Type 2 Diabetics	PHASE1	COMPLETED
Effect of Non-Alcoholic Steatohepatitis (NASH) on the Pharmacokinetics of 99mTechnetium-Mebrofenin	PHASE1	COMPLETED
Effect of Obeticholic Acid on Transport of Bile Acids in PBC Examined by 11C-cholyl-sarcosine PET/CT	EARLY_PHASE1	COMPLETED
PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Cholestatic Disorders in Patients with Genetic Liver Disorders and Healthy Individuals	nan	ENROLLING_BY_INVITATION
Regulation of Human Intestinal Bile Acid Transport in Health and Disease	nan	COMPLETED
FGF19 in Obstructive Cholestasis: Unveil the Signal	nan	UNKNOWN
Gut Transit Effect on Enterohepatic Circulation	nan	COMPLETED
Gene Expression in Inflammatory Bowel Disease	nan	ENROLLING_BY_INVITATION
Bile Acids Metabolism and Genetic Mutation Profile in the Intrahepatic Cholestasis of Pregnacy in Indian Population	nan	RECRUITING
The Role of Faecal Bile Acids in the Management of Bile Acid Diarrhoea	nan	COMPLETED
Effects of Colesevelam HCl On Bile Acid Kinetics	nan	COMPLETED
Pediatric Evaluation and Registry for Liver Cholestasis in Canada	nan	RECRUITING
Intralumenal Effects on Cholesterol Absorption/Synthesis	nan	COMPLETED
Mechanisms of Glucose Lowering Effect of Colesevelam HCl	nan	COMPLETED
Expression of BCRP in Icteric Patients	nan	COMPLETED
The Microbiome Composition in Women With Recurring Intrahepatic Cholestasis of Pregnancy (ICP)	nan	COMPLETED
A Trial of Taurine Supplementation in Parenteral Nutrition 1	nan	UNKNOWN
The Effects of the Bile Acid Supplement, 7-keto Lithocholic Acid, on Human Gut Microbiota and Risk Factors for Disease.	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a SLC10A2 binder may also engage these)

Protein	Name	Similarity
Q62633	—	1.000	Q62633 →
P70172	—	1.000	P70172 →
Q60414	—	1.000	Q60414 →
Q28727	—	0.999	Q28727 →
SLC10A6	Sodium-dependent organic anion transporter	0.958	landscape →
Q5R6B8	—	0.955	Q5R6B8 →
SLC9B2	Sodium/hydrogen exchanger 9B2	0.952	landscape →
A6QP84	—	0.949	A6QP84 →
Q3UEZ8	—	0.948	Q3UEZ8 →
Q5PT56	—	0.948	Q5PT56 →
A0A6P3HVI0	—	0.948	A0A6P3HVI0 →
Q5BKR2	—	0.947	Q5BKR2 →
Q96EP9	—	0.944	Q96EP9 →
A4IHB9	—	0.942	A4IHB9 →
Q70EX6	—	0.941	Q70EX6 →
Q9CXB2	—	0.940	Q9CXB2 →
Q6DEJ6	—	0.940	Q6DEJ6 →
Q91WC7	—	0.938	Q91WC7 →
Q0IHM1	—	0.936	Q0IHM1 →
Q5U3U7	—	0.936	Q5U3U7 →
Q8NA29	—	0.936	Q8NA29 →
Q8TF71	—	0.936	Q8TF71 →
Q8BH31	—	0.936	Q8BH31 →
Q3MHW6	—	0.936	Q3MHW6 →
Q9DA75	—	0.935	Q9DA75 →
A1L1W9	—	0.935	A1L1W9 →
O35874	—	0.934	O35874 →
Q8NHS3	—	0.934	Q8NHS3 →
Q9H841	—	0.933	Q9H841 →
Q0VA82	—	0.933	Q0VA82 →