SCHEMBL1387665

SCHEMBL1387665

CCCC[C@]1(CC)CSc2cc(OC)c(COC)cc2[C@H](c2ccccc2)N1

nearest known ligand 0.55

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SLC10A2 Q12908 20/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1387664 1.00 SLC10A2 (0.55) SLC10A2
SCHEMBL1388965 0.91 SLC10A2 (0.54) SLC10A2
SCHEMBL1388964 0.91 SLC10A2 (0.54) SLC10A2
SCHEMBL7472527 0.91 SLC10A2 (0.63) SLC10A2
SCHEMBL2581999 0.91 SLC10A2 (0.63) SLC10A2
SCHEMBL7472523 0.91 SLC10A2 (0.63) SLC10A2
SCHEMBL2582109 0.91 SLC10A2 (0.63) SLC10A2
SCHEMBL1388901 0.89 SLC10A2 (0.53) SLC10A2
SCHEMBL2589578 0.88 SLC10A2 (0.57) SLC10A2
SCHEMBL2590981 0.88 SLC10A2 (0.57) SLC10A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-H10504035-A 1998-04-14 JP claimed
EP-0775126-A1 HYPOLIPIDEMIC 1,4-BENZOTHIAZEPINE-1,1-DIOXIDES THE WELLCOME FOUNDATION LIMITED (GB) 1997-05-28 EP claimed
WO-1996005188-A1 HYPOLIPIDEMIC 1,4-BENZOTHIAZEPINE-1,1-DIOXIDES THE WELLCOME FOUNDATION LIMITED (GB) 1996-02-22 WO claimed
EP-0971744-A2 COMBINATION THERAPY EMPLOYING ILEAL BILE ACID TRANSPORT INHIBITING BENZOTHIEPINES AND HMG Co-A REDUCTASE INHIBITORS G.D. SEARLE & CO. (US) 2000-01-19 EP disclosed
WO-1998040375-A2 COMBINATION OF ILEAL BILE ACID TRANSPORT INHIBITING BENZOTHIEPINES AND HMG Co-A REDUCTASE INHIBITORS G.D. SEARLE & CO. (US) 1998-09-17 WO disclosed