SCHEMBL1387723

SCHEMBL1387723

CC1(CO)NC(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C1=O

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 11/20 0.73
PGR P06401 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1387749 0.86 AR (0.70) ARPGR
SCHEMBL629858 0.84 AR (1.00) ARPGR
SCHEMBL1773488 0.83 AR (0.65) ARPGR
SCHEMBL1712475 0.83 AR (1.00) ARPGR
SCHEMBL10327266 0.83 AR (1.00) ARPGR
SCHEMBL10327487 0.83 AR (1.00) ARPGR
SCHEMBL332642 0.82 AR (0.76) ARPGR
SCHEMBL16167927 0.82 AR (0.64) ARPGR
SCHEMBL3489730 0.82 AR (0.83) ARPGR
Acetic Acid SCHEMBL7784177 0.82 AR (0.89) ARPGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0738263-B1 SUBSTITUTED PHENYLIMIDAZOLIDINES HAVING ANTIANDROGEN ACTIVITY AVENTIS PHARMA SA (FR) 2001-04-04 EP claimed
US-5750553-A ANTIANDROGENIC AGENTS ROUSSEL UCLAF (FR) 1998-05-12 US claimed
JP-H09507241-A 1997-07-22 JP claimed
EP-0738263-A1 NOVEL OPTIONALLY SUBSTITUTED PHENYLIMIDAZOLIDINES, INTERMEDIATES AND PROCESS FOR THEIR PREPARATION, THEIR USE AS DRUGS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ROUSSEL UCLAF (FR) 1996-10-23 EP claimed
WO-1995018794-A1 NOVEL OPTIONALLY SUBSTITUTED PHENYLIMIDAZOLIDINES, INTERMEDIATES AND PROCESS FOR THEIR PREPARATION, THEIR USE AS DRUGS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ROUSSEL UCLAF (FR) 1995-07-13 WO claimed
CN-1113873-C Novel optionally substituted phenylimidazolidines, intermediates and process for prepn. thereof, use as drugs and pharmaceutical compositions contg. same ROUSSEL UCLAF CORP (FR) 2003-07-09 CN disclosed
EP-0738263-B1 SUBSTITUTED PHENYLIMIDAZOLIDINES HAVING ANTIANDROGEN ACTIVITY AVENTIS PHARMA SA (FR) 2001-04-04 EP disclosed
US-5750553-A ANTIANDROGENIC AGENTS ROUSSEL UCLAF (FR) 1998-05-12 US disclosed
CN-1141631-A Novel optionally substituted phenylimidazolidines, intermediates and process for prepn. thereof, use as drugs and pharmaceutical compositions contg. same ROUSSEL UCLAF CORP (FR) 1997-01-29 CN disclosed
EP-0738263-A1 NOVEL OPTIONALLY SUBSTITUTED PHENYLIMIDAZOLIDINES, INTERMEDIATES AND PROCESS FOR THEIR PREPARATION, THEIR USE AS DRUGS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ROUSSEL UCLAF (FR) 1996-10-23 EP disclosed
WO-1995018794-A1 NOVEL OPTIONALLY SUBSTITUTED PHENYLIMIDAZOLIDINES, INTERMEDIATES AND PROCESS FOR THEIR PREPARATION, THEIR USE AS DRUGS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ROUSSEL UCLAF (FR) 1995-07-13 WO disclosed