Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.69 |
| ▸ | DRD3 | P35462 | 11/20 | 0.69 |
| ▸ | DRD4 | P21917 | 8/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388028 | 0.96 | DRD2 (0.69) | DRD2DRD3DRD4SLC6A2SLC6A4 | |
| SCHEMBL1388189 | 0.91 | DRD2 (0.72) | DRD2DRD3DRD4SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL8980926 | 0.90 | DRD2 (0.70) | DRD2DRD3DRD4SLC6A2SLC6A4 | |
| SCHEMBL1387965 | 0.88 | DRD2 (0.70) | DRD2DRD3DRD4SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL8980714 | 0.87 | DRD2 (0.69) | DRD2DRD3DRD4SLC6A2SLC6A4 | |
| SCHEMBL1388194 | 0.85 | DRD2 (0.72) | DRD2DRD3DRD4SLC6A2SLC6A4 | |
| SCHEMBL1388239 | 0.85 | DRD2 (0.74) | DRD2DRD3DRD4SLC6A2SLC6A4 | |
| SCHEMBL10908587 | 0.84 | DRD2 (0.83) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL1388213 | 0.84 | DRD2 (0.70) | DRD2DRD3DRD4SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL8980742 | 0.84 | DRD2 (0.73) | DRD2DRD3DRD4SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-H09500883-A | — | — | 1997-01-28 | — | — | JP | claimed |
| CN-1132508-A | Piperazine derivatives | REORDATI IND CHIMICA E FARMACE (CH) | 1996-10-02 | — | — | CN | claimed |
| EP-0711288-A1 | PIPERAZINE DERIVATIVES AS ALPHA 1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 1996-05-15 | — | — | EP | claimed |
| WO-1995004049-A1 | PIPERAZINE DERIVATIVES AS α1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-02-09 | — | — | WO | claimed |
| EP-0711288-A1 | PIPERAZINE DERIVATIVES AS ALPHA 1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004049-A1 | PIPERAZINE DERIVATIVES AS α1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-02-09 | — | — | WO | disclosed |