Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ITGAL | P20701 | 6/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | DRD3 | P35462 | 3/20 | 0.51 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.51 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13879651 | 0.84 | ITGAL (0.57) | KDM4EALDH1A1SMN1; SMN2ITGALHPGD | |
| SCHEMBL13879614 | 0.83 | CYP3A4 (0.64) | CYP3A4CYP2C19KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL13879647 | 0.82 | ITGAL (0.75) | KDM4EITGALHPGDITGB2ICAM1 | |
| SCHEMBL4276627 | 0.82 | ITGAL (0.57) | KDM4EALDH1A1SMN1; SMN2ITGALHPGD | |
| SCHEMBL4276624 | 0.82 | ITGAL (0.57) | KDM4EALDH1A1SMN1; SMN2ITGALHPGD | |
| SCHEMBL13879663 | 0.82 | ITGAL (0.58) | KDM4EALDH1A1ITGALHPGDDRD2 | |
| SCHEMBL4277183 | 0.82 | ITGAL (0.58) | ITGALDRD2DRD3ITGB2ICAM1 | |
| SCHEMBL4277179 | 0.82 | ITGAL (0.58) | ITGALDRD2DRD3ITGB2ICAM1 | |
| SCHEMBL13879654 | 0.81 | ITGAL (0.63) | ALDH1A1SMN1; SMN2ITGALDRD2DRD3 | |
| SCHEMBL4280079 | 0.80 | ITGAL (0.55) | KDM4EALDH1A1ITGALHPGDDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099186-A1 | INHIBITORS OF VIRAL REPLICATION | INTERMUNE, INC. | 2009-04-16 | — | — | US | disclosed |
| US-20090099186-A1 | INHIBITORS OF VIRAL REPLICATION | INTERMUNE, INC. | 2009-04-16 | — | — | US | disclosed |
| WO-2007047146-A2 | INHIBITORS OF VIRAL REPLICATION | INTERMUNE, INC. (US) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099186-A1 | INHIBITORS OF VIRAL REPLICATION | EIF2AK2, HAVCR2, RTF2 | CYP3A4 1385/4885CYP2C19 2487/4885KDM4E 797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.