Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 9/20 | 0.52 |
| ▸ | ICAM1 | P05362 | 9/20 | 0.52 |
| ▸ | ITGAL | P20701 | 9/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13879617 | 0.88 | ITGB2 (0.60) | ITGB2ICAM1ITGALGAANPC1 | |
| SCHEMBL13879679 | 0.80 | SMN1; SMN2 (0.41) | ITGB2ICAM1ITGALGAASMN1; SMN2 | |
| SCHEMBL13879627 | 0.79 | ITGB2 (0.58) | ITGB2ICAM1ITGALGAANPC1 | |
| SCHEMBL13879678 | 0.79 | CYP3A4 (0.52) | SMN1; SMN2CYP2C19KMT2ACYP3A4KDM4E | |
| SCHEMBL13879681 | 0.79 | ITGB2 (0.51) | ITGB2ICAM1ITGALNAMPTKDM4E | |
| SCHEMBL13879687 | 0.78 | MAOB (0.40) | ITGALGAANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6310393 | 0.75 | ITGAL (0.58) | ITGB2ICAM1ITGALSMN1; SMN2KDM4E | |
| SCHEMBL13879685 | 0.73 | SMN1; SMN2 (0.41) | ITGALGAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13879654 | 0.73 | ITGAL (0.63) | ITGB2ICAM1ITGALNPC1RAB9A | |
| SCHEMBL7064969 | 0.73 | ITGB2 (0.49) | ITGB2ICAM1ITGALNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099186-A1 | INHIBITORS OF VIRAL REPLICATION | INTERMUNE, INC. | 2009-04-16 | — | — | US | disclosed |
| US-20090099186-A1 | INHIBITORS OF VIRAL REPLICATION | INTERMUNE, INC. | 2009-04-16 | — | — | US | disclosed |
| WO-2007047146-A2 | INHIBITORS OF VIRAL REPLICATION | INTERMUNE, INC. (US) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099186-A1 | INHIBITORS OF VIRAL REPLICATION | EIF2AK2, HAVCR2, RTF2 | ITGB2 4487/4885ICAM1 2947/4885ITGAL 4495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.