Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 13/20 | 0.69 |
| ▸ | DRD3 | P35462 | 5/20 | 0.58 |
| ▸ | DRD2 | P14416 | 5/20 | 0.58 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388460 | 0.89 | DRD4 (0.67) | DRD4DRD3DRD2GRIN1GRIN2B | |
| SCHEMBL1388288 | 0.87 | DRD4 (0.65) | DRD4DRD3DRD2GRIN1GRIN2B | |
| SCHEMBL1388264 | 0.85 | DRD4 (0.65) | DRD4DRD3DRD2GRIN1GRIN2B | |
| SCHEMBL1388197 | 0.81 | DRD4 (1.00) | DRD4DRD3DRD2GRIN1GRIN2B | |
| SCHEMBL1388193 | 0.81 | DRD4 (0.65) | DRD4DRD3DRD2GRIN1GRIN2B | |
| SCHEMBL14173475 | 0.80 | DRD4 (0.54) | DRD4DRD3DRD2GRIN1GRIN2B | |
| SCHEMBL5626446 | 0.78 | DRD4 (0.74) | DRD4DRD2GRIN1GRIN2BHTT | |
| SCHEMBL5242533 | 0.77 | SLC6A4 (0.53) | DRD4DRD3DRD2HTT | |
| SCHEMBL1388159 | 0.77 | DRD4 (0.66) | DRD4DRD3DRD2GRIN1GRIN2B | |
| SCHEMBL1388210 | 0.77 | DRD4 (0.66) | DRD4DRD3DRD2GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235572-A2 | METHOD TO TREAT PAIN UTILIZING BENZIMIDAZOLE NMDA/NR2B ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2002-09-04 | — | — | EP | claimed |
| US-6362196-B1 | N-METHYLASPARATIC ACID ANTAGONIST | MERCK & CO., INC. | 2002-03-26 | — | — | US | claimed |
| WO-2001030330-A2 | METHOD TO TREAT PAIN UTILIZING BENZIMIDAZOLE NMDA/NR2B ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 2001-05-03 | — | — | WO | claimed |
| EP-0689535-B1 | BENZIMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1998-09-23 | — | — | EP | claimed |
| JP-H08508030-A | — | — | 1996-08-27 | — | — | JP | claimed |
| EP-0689535-A1 | BENZIMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1996-01-03 | — | — | EP | claimed |
| WO-1994021615-A1 | BENZIMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-29 | — | — | WO | claimed |
| EP-1235572-A2 | METHOD TO TREAT PAIN UTILIZING BENZIMIDAZOLE NMDA/NR2B ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2002-09-04 | — | — | EP | disclosed |
| US-6362196-B1 | N-METHYLASPARATIC ACID ANTAGONIST | MERCK & CO., INC. | 2002-03-26 | — | — | US | disclosed |
| WO-2001030330-A2 | METHOD TO TREAT PAIN UTILIZING BENZIMIDAZOLE NMDA/NR2B ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 2001-05-03 | — | — | WO | disclosed |
| EP-0689535-B1 | BENZIMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1998-09-23 | — | — | EP | disclosed |
| US-5714498-A | Benzimidazole derivatives | MERCK, SHARP, & DOHME, LTD. (GB) | 1998-02-03 | — | — | US | disclosed |
| EP-0689535-A1 | BENZIMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1996-01-03 | — | — | EP | disclosed |
| WO-1994021615-A1 | BENZIMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-29 | — | — | WO | disclosed |