Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 14/20 | 0.74 |
| ▸ | HTT | P42858 | 1/20 | 0.73 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.71 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | DRD2 | P14416 | 2/20 | 0.69 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.62 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9202923 | 0.96 | HTT (0.76) | DRD4HTTGRIN1GRIN2BHPGD | |
| SCHEMBL5157052 | 0.92 | HTT (0.84) | DRD4HTTGRIN1GRIN2BHPGD | |
| SCHEMBL8688980 | 0.89 | DRD4 (0.67) | DRD4HTTGRIN1GRIN2BHPGD | |
| SCHEMBL12045417 | 0.86 | HTT (0.97) | DRD4HTTGRIN1GRIN2BHPGD | |
| SCHEMBL29368802 | 0.86 | HTT (0.97) | DRD4HTTGRIN1GRIN2BHPGD | |
| SCHEMBL4809921 | 0.85 | DRD4 (1.00) | DRD4HTTHPGDDRD2GRM2 | |
| SCHEMBL5412340 | 0.85 | HTT (0.73) | DRD4HTTHPGDDRD2NPC1 | |
| SCHEMBL5412335 | 0.85 | HTT (0.73) | DRD4HTTGRIN1GRIN2BHPGD | |
| SCHEMBL18306556 | 0.85 | HTT (0.73) | DRD4HTTGRIN1GRIN2BHPGD | |
| SCHEMBL7972912 | 0.85 | GRIN2B (0.83) | DRD4HTTGRIN1GRIN2BHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792768-A | Antipsychotic benzimidazole derivatives | MERCK, SHARP & DOHME LIMITED (GB) | 1998-08-11 | — | — | US | claimed |
| EP-0691960-B1 | ANTIPSYCHOTIC BENZIMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1997-12-03 | — | — | EP | claimed |
| EP-0691960-A1 | ANTIPSYCHOTIC BENZIMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1996-01-17 | — | — | EP | claimed |
| WO-1994022839-A1 | ANTIPSYCHOTIC BENZIMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-10-13 | — | — | WO | claimed |
| US-7160879-B2 | Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1H-benzoimidazole analogues | NEUROGEN CORPORATION (US) | 2007-01-09 | — | — | US | disclosed |
| US-7160879-B2 | Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1H-benzoimidazole analogues | NEUROGEN CORPORATION (US) | 2007-01-09 | — | — | US | disclosed |
| EP-1465635-A4 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 2-(4-BENZYL-PIPERAZIN-1-YLMETHYL)- AND 2-(4-BENZYL-DIAZEPAN-1-YLMETHYL)-1H-BENZOIMIDAZOLE ANALOGUES | NEUROGEN CORP (US) | 2005-04-13 | — | — | EP | disclosed |
| EP-1465635-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 2-(4-BENZYL-PIPERAZIN-1-YLMETHYL)- AND 2-(4-BENZYL-DIAZEPAN-1-YLMETHYL)-1H-BENZOIMIDAZOLE ANALOGUES | NEUROGEN CORPORATION (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003060475-A3 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 2-(4-BENZYL-PIPERAZIN-1-YLMETHYL)- AND 2-(4-BENZYL-DIAZEPAN-1-YLMETHYL)-1H-BENZOIMIDAZOLE ANALOGUES | NEUROGEN CORP (US) | 2003-12-31 | — | — | WO | disclosed |
| US-20030229074-A1 | Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1H-benzoimidazole analogues | NEUROGEN CORPORATION | 2003-12-11 | — | — | US | disclosed |
| US-20030229074-A1 | Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1H-benzoimidazole analogues | NEUROGEN CORPORATION | 2003-12-11 | — | — | US | disclosed |
| WO-2003060475-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 2-(4-BENZYL-PIPERAZIN-1-YLMETHYL)- AND 2-(4-BENZYL-DIAZEPAN-1-YLMETHYL)-1H-BENZOIMIDAZOLE ANALOGUES | NEUROGEN CORPORATION (US) | 2003-07-24 | — | — | WO | disclosed |
| US-5792768-A | Antipsychotic benzimidazole derivatives | MERCK, SHARP & DOHME LIMITED (GB) | 1998-08-11 | — | — | US | disclosed |
| EP-0691960-B1 | ANTIPSYCHOTIC BENZIMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1997-12-03 | — | — | EP | disclosed |
| EP-0691960-A1 | ANTIPSYCHOTIC BENZIMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994022839-A1 | ANTIPSYCHOTIC BENZIMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-10-13 | — | — | WO | disclosed |
| EP-0123962-B1 | BENZIMIDAZOLE DERIVATIVE, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION | KANEBO, LTD. (JP) | 1989-12-27 | — | — | EP | disclosed |
| US-4603130-A | ANTIHISTAMINES | KANEBO, LTD. (JP) | 1986-07-29 | — | — | US | disclosed |
| EP-0123962-A2 | Benzimidazole derivative, process for the preparation thereof and pharmaceutical composition | KANEBO, LTD. (JP) | 1984-11-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229074-A1 | Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1H-benzoimidazole analogues | MCHR1, MCHR2, MC1R | DRD4 447/4885HTT 786/4885GRIN1 819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.