Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 4/20 | 0.63 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.63 |
| ▸ | HTR3B | O95264 | 2/20 | 0.63 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.63 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.63 |
| ▸ | HTR5A | P47898 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13881186 | 1.00 | HTR3A (0.63) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL13881240 | 1.00 | HTR3A (0.63) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL13881236 | 0.86 | HTR3A (0.52) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL19996959 | 0.84 | CHRNA7 (0.61) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL6101742 | 0.82 | CHRNA7 (0.65) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL19996931 | 0.82 | CHRNA7 (0.61) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL4936129 | 0.82 | CHRNA7 (0.61) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Hydrochloric Acid SCHEMBL6100174 | 0.81 | CHRNA7 (0.64) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Hydrochloric Acid SCHEMBL9706325 | 0.81 | MAPK1 (0.80) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL5917929 | 0.80 | CHRNA7 (0.65) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2564850-A1 | Polo-like kinase inhibitors | Takeda Pharmaceutical Company Limited (JP) | 2013-03-06 | — | — | EP | disclosed |
| WO-2009040556-A1 | PYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CYCLACEL LIMITED (GB) | 2009-04-02 | — | — | WO | disclosed |
| WO-2009042711-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-02 | — | — | WO | disclosed |