Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3548018 | 0.91 | HTR4 (0.57) | HTR4KDM4EMEN1MAPTKMT2A | |
| SCHEMBL3936747 | 0.91 | HTR4 (0.57) | HTR4KDM4EMEN1MAPTKMT2A | |
| SCHEMBL1560183 | 0.88 | HTR4 (0.63) | HTR4KDM4EMEN1MAPTKMT2A | |
| SCHEMBL13175586 | 0.87 | HTR4 (0.53) | HTR4CHRM4CHRM5ADRA2CCHRM3 | |
| SCHEMBL13175766 | 0.86 | HTR4 (0.50) | HTR4MEN1KMT2ACHRM4CHRM5 | |
| SCHEMBL2546256 | 0.83 | MAPK14 (0.52) | HTR4MEN1MAPTKMT2A | |
| SCHEMBL13175824 | 0.83 | HRH3 (0.49) | HTR4MEN1KMT2ACYP2D6CYP2C9 | |
| SCHEMBL12893438 | 0.82 | HTR4 (0.52) | HTR4KDM4EMEN1MAPTKMT2A | |
| SCHEMBL12893778 | 0.82 | HTR4 (0.52) | HTR4KDM4EMEN1MAPTKMT2A | |
| SCHEMBL12825889 | 0.82 | HTR4 (0.55) | HTR4CHRM4CHRM5ADRA2CCHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2564850-A1 | Polo-like kinase inhibitors | Takeda Pharmaceutical Company Limited (JP) | 2013-03-06 | — | — | EP | disclosed |
| WO-2009042711-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-02 | — | — | WO | disclosed |