Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4224982 | 0.73 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3DRD2DRD4 | |
| SCHEMBL16863269 | 0.73 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3DRD2DRD4 | |
| SCHEMBL26749370 | 0.73 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3DRD2DRD4 | |
| SCHEMBL12708991 | 0.73 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3DRD2DRD4 | |
| SCHEMBL12728994 | 0.73 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3DRD2DRD4 | |
| SCHEMBL23938030 | 0.73 | DRD2 (0.49) | SLC6A2SLC6A4SLC6A3DRD2DRD4 | |
| SCHEMBL22714880 | 0.70 | MAP4K4 (0.37) | SLC6A2SLC6A4SLC6A3DRD2DRD4 | |
| SCHEMBL12610026 | 0.70 | IDH1 (0.42) | SLC6A2SLC6A4SLC6A3PDE4APDE4B | |
| SCHEMBL30977594 | 0.70 | DRD2 (0.37) | SLC6A2SLC6A4SLC6A3DRD2DRD4 | |
| SCHEMBL24566036 | 0.70 | CYP19A1 (0.40) | SLC6A2SLC6A4SLC6A3DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009047506-A1 | BICYCLIC HETEROCYCLIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2009-04-16 | — | — | WO | disclosed |