Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 16/20 | 0.54 |
| ▸ | CDK2 | P24941 | 4/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.54 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13885183 | 0.91 | CHEK1 (0.56) | CHEK1CDK2CCNA2CCNA1GSK3B | |
| SCHEMBL13998511 | 0.84 | GSK3B (0.67) | CHEK1CDK2CCNA2CCNA1GSK3B | |
| SCHEMBL14528738 | 0.80 | CHEK1 (0.56) | CHEK1CDK2CCNA2CCNA1GSK3B | |
| SCHEMBL13885182 | 0.79 | GSK3B (0.58) | CHEK1CDK2CCNA2CCNA1GSK3B | |
| SCHEMBL13885060 | 0.79 | GSK3B (0.60) | CHEK1CDK2CCNA2CCNA1GSK3B | |
| SCHEMBL13998548 | 0.79 | GSK3B (0.73) | CHEK1CDK2CCNA2CCNA1GSK3B | |
| SCHEMBL14541702 | 0.79 | GSK3B (0.58) | CHEK1CDK2CCNA2CCNA1GSK3B | |
| SCHEMBL14541358 | 0.78 | CHEK1 (0.57) | CHEK1CDK2CCNA2CCNA1GSK3B | |
| SCHEMBL14218800 | 0.77 | CHEK1 (0.61) | CHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13885699 | 0.77 | GSK3B (0.43) | CHEK1CDK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514442-B2 | Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2009-04-07 | — | — | US | disclosed |