Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 17/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.55 |
| ▸ | CDK2 | P24941 | 2/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13998511 | 0.88 | GSK3B (0.67) | GSK3BCHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14516625 | 0.85 | CHEK1 (0.64) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14218820 | 0.85 | CHEK1 (0.57) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11931079 | 0.85 | CHEK1 (0.75) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL13998548 | 0.83 | GSK3B (0.73) | GSK3BCHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL13885183 | 0.81 | CHEK1 (0.56) | GSK3BCHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL13885701 | 0.79 | CHEK1 (0.54) | GSK3BCHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL13309478 | 0.78 | GPR119 (0.44) | GSK3BCHEK1 | |
| SCHEMBL14541358 | 0.77 | CHEK1 (0.57) | GSK3BCHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL13998492 | 0.76 | GSK3B (0.64) | GSK3BCHEK1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044420-A1 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS FOR THE TREATMENT OF CANCER | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |