Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.63 |
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | EGFR | P00533 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | LCK | P06239 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | NEK2 | P51955 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30856935 | 1.00 | MCL1 (0.66) | MCL1KDM4EMAPTEGFRALDH1A1 | |
| SCHEMBL1388796 | 1.00 | MCL1 (0.66) | MCL1KDM4EMAPTEGFRALDH1A1 | |
| SCHEMBL20523573 | 0.86 | EGFR (0.62) | MCL1KDM4EEGFRALDH1A1ERBB2 | |
| SCHEMBL1388545 | 0.84 | MAPT (0.63) | MCL1KDM4EMAPTEGFRALDH1A1 | |
| SCHEMBL1388543 | 0.84 | MAPT (0.63) | MCL1KDM4EMAPTEGFRALDH1A1 | |
| SCHEMBL17120687 | 0.81 | MAPT (0.58) | MCL1KDM4EMAPTEGFRALDH1A1 | |
| SCHEMBL21470204 | 0.81 | ALDH1A1 (0.55) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL11674085 | 0.80 | EGFR (0.46) | MCL1KDM4EMAPTEGFRALDH1A1 | |
| SCHEMBL1692376 | 0.80 | MCL1 (1.00) | MCL1KDM4EMAPTEGFRALDH1A1 | |
| SCHEMBL1692375 | 0.80 | MCL1 (1.00) | MCL1KDM4EMAPTEGFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0987263-A2 | Arylidene and heteroarylidene oxindole derivatives as tyrosine kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-03-22 | — | — | EP | claimed |
| JP-H08500847-A | — | — | 1996-01-30 | — | — | JP | claimed |
| EP-0658159-A1 | ARYLIDENE AND HETEROARYLIDENE OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-06-21 | — | — | EP | claimed |
| WO-1995001349-A1 | ARYLIDENE AND HETEROARYLIDENE OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1995-01-12 | — | — | WO | claimed |
| CN-117916225-A | N-heterocyclyl substituted 2-cyano-3- (naphthalen-2-yl) acrylamide derivatives as fluorophores for detection of amyloid and amyloid-like proteins for diagnosis of neurodegenerative disorders | 阿米达斯公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-117916225-A | N-heterocyclyl substituted 2-cyano-3- (naphthalen-2-yl) acrylamide derivatives as fluorophores for detection of amyloid and amyloid-like proteins for diagnosis of neurodegenerative disorders | 阿米达斯公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-117916225-A | N-heterocyclyl substituted 2-cyano-3- (naphthalen-2-yl) acrylamide derivatives as fluorophores for detection of amyloid and amyloid-like proteins for diagnosis of neurodegenerative disorders | 阿米达斯公司 | 2024-04-19 | — | — | CN | disclosed |
| EP-0987263-B1 | Arylidene and heteroarylidene oxindole derivatives as tyrosine kinase inhibitors | PFIZER ITALIA SRL (IT) | 2007-04-18 | — | — | EP | disclosed |
| EP-0987263-A2 | Arylidene and heteroarylidene oxindole derivatives as tyrosine kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-03-22 | — | — | EP | disclosed |
| US-5656654-A | TYROSINE KINASE INHIBITORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1997-08-12 | — | — | US | disclosed |
| EP-0558950-B1 | 3-aryl-glycidic ester derivatives and process for their preparation | PHARMACIA SPA (IT) | 1996-12-04 | — | — | EP | disclosed |
| US-5436235-A | 3-aryl-glycidic ester derivatives | FARMITALIA CARLO ERBA S.R.L. (IT) | 1995-07-25 | — | — | US | disclosed |
| EP-0658159-A1 | ARYLIDENE AND HETEROARYLIDENE OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-06-21 | — | — | EP | disclosed |
| WO-1995001349-A1 | ARYLIDENE AND HETEROARYLIDENE OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1995-01-12 | — | — | WO | disclosed |
| EP-0558950-A1 | 3-aryl-glycidic ester derivatives and process for their preparation | PHARMACIA S.p.A. (IT) | 1993-09-08 | — | — | EP | disclosed |