Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | APP | P05067 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | USP2 | O75604 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29397736 | 1.00 | POLB (0.70) | POLBALDH1A1MAPTAPPNPC1 | |
| SCHEMBL1388803 | 1.00 | POLB (0.70) | POLBALDH1A1MAPTAPPNPC1 | |
| SCHEMBL7463677 | 1.00 | POLB (0.70) | POLBALDH1A1MAPTAPPNPC1 | |
| SCHEMBL30379249 | 0.87 | POLB (0.71) | POLBALDH1A1MAPTAPPNPC1 | |
| SCHEMBL9361448 | 0.87 | POLB (0.71) | POLBALDH1A1MAPTAPPNPC1 | |
| SCHEMBL15232445 | 0.87 | POLB (0.71) | POLBALDH1A1MAPTAPPNPC1 | |
| SCHEMBL2047819 | 0.87 | POLB (0.71) | POLBALDH1A1MAPTAPPNPC1 | |
| SCHEMBL15121369 | 0.83 | ALDH1A1 (0.74) | POLBALDH1A1MAPTAPPNPC1 | |
| SCHEMBL15121370 | 0.83 | ALDH1A1 (0.74) | POLBALDH1A1MAPTAPPNPC1 | |
| SCHEMBL7456830 | 0.82 | EGFR (0.60) | POLBALDH1A1MAPTAPPNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0987263-A2 | Arylidene and heteroarylidene oxindole derivatives as tyrosine kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-03-22 | — | — | EP | claimed |
| JP-H08500847-A | — | — | 1996-01-30 | — | — | JP | claimed |
| EP-0658159-A1 | ARYLIDENE AND HETEROARYLIDENE OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-06-21 | — | — | EP | claimed |
| WO-1995001349-A1 | ARYLIDENE AND HETEROARYLIDENE OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1995-01-12 | — | — | WO | claimed |
| EP-0987263-B1 | Arylidene and heteroarylidene oxindole derivatives as tyrosine kinase inhibitors | PFIZER ITALIA SRL (IT) | 2007-04-18 | — | — | EP | disclosed |
| EP-0987263-A2 | Arylidene and heteroarylidene oxindole derivatives as tyrosine kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-03-22 | — | — | EP | disclosed |
| US-5656654-A | TYROSINE KINASE INHIBITORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1997-08-12 | — | — | US | disclosed |
| EP-0658159-A1 | ARYLIDENE AND HETEROARYLIDENE OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-06-21 | — | — | EP | disclosed |
| WO-1995001349-A1 | ARYLIDENE AND HETEROARYLIDENE OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1995-01-12 | — | — | WO | disclosed |