Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | DRD1 | P21728 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388980 | 0.84 | DRD4 (0.48) | DRD4KDRRAB9ADRD3KMT2A | |
| SCHEMBL1388946 | 0.82 | HRH3 (0.49) | HTR3ADRD4NPC1RAB9AMAPK1 | |
| SCHEMBL1389022 | 0.78 | KDR (0.52) | DRD4KDRDRD2 | |
| SCHEMBL1388900 | 0.76 | DRD3 (0.49) | DRD4DRD3DRD2 | |
| SCHEMBL8797340 | 0.75 | HTR3A (0.51) | HTR3ADRD4KCNH2NPC1RAB9A | |
| SCHEMBL1389143 | 0.74 | CD44 (0.49) | DRD4KDRNPC1DRD3KMT2A | |
| SCHEMBL1388929 | 0.73 | PARP1 (0.49) | DRD4KDRDRD3KMT2AMEN1 | |
| SCHEMBL8923621 | 0.72 | HTR3A (0.50) | HTR3ADRD4NPC1RAB9ADRD3 | |
| SCHEMBL8651329 | 0.71 | HTR3A (0.46) | HTR3ADRD4KCNH2NPC1RAB9A | |
| SCHEMBL1388880 | 0.70 | DRD4 (0.45) | DRD4KDRDRD3KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717733-B1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME (GB) | 1997-12-03 | — | — | EP | claimed |
| JP-H09502199-A | — | — | 1997-03-04 | — | — | JP | claimed |
| EP-0717733-A1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 1996-06-26 | — | — | EP | claimed |
| WO-1995007262-A1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1995-03-16 | — | — | WO | claimed |
| EP-0717733-B1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME (GB) | 1997-12-03 | — | — | EP | disclosed |
| US-5686480-A | Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands | MERCK, SHARP & DOHME, LTD. (GB) | 1997-11-11 | — | — | US | disclosed |
| EP-0717733-A1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 1996-06-26 | — | — | EP | disclosed |
| WO-1995007262-A1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1995-03-16 | — | — | WO | disclosed |