Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12446720 | 0.85 | HSP90AA1 (0.45) | PKMPOLBALDH1A1HIF1AHSD17B1 | |
| SCHEMBL13889415 | 0.85 | ACE2 (0.58) | ALDH1A1TSHRACE2HSP90AA1HSP90AB1 | |
| SCHEMBL13895736 | 0.84 | MAPK1 (0.45) | ALDH1A1TSHRACE2HSP90AA1HSP90AB1 | |
| SCHEMBL28407172 | 0.82 | ACE2 (0.41) | ALDH1A1ACE2HSP90AA1HSP90AB1 | |
| SCHEMBL19658025 | 0.81 | HSP90AA1 (0.49) | ALDH1A1ACE2HSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL13377058 | 0.80 | CYP2A6 (0.47) | PKMALDH1A1CREBBPACE2CYP2A6 | |
| SCHEMBL13651423 | 0.79 | HSP90AA1 (0.46) | PKMPOLBALDH1A1HIF1ATSHR | |
| SCHEMBL3279437 | 0.78 | PKM (0.57) | PKMPOLBALDH1A1HIF1AHSD17B1 | |
| SCHEMBL26030945 | 0.77 | CREBBP (0.59) | ALDH1A1HIF1ATSHRHTTCREBBP | |
| SCHEMBL27821688 | 0.77 | GAA (0.53) | POLBALDH1A1TSHRHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629141-B2 | Spiro-oxindole MDM2 antagonists | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-01-14 | — | — | US | disclosed |
| US-20120289494-A1 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | SANOFI (FR) | 2012-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289494-A1 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | TP53, MDM2, TP53BP1 | PKM 3114/4885POLB 2024/4885ALDH1A1 1498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.