Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 6/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | KHK | P50053 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | STAT3 | P40763 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1638215 | 0.91 | CRHR1 (0.48) | CRHR1TDP1KHKJAK2ABL1 | |
| SCHEMBL14276724 | 0.88 | CRHR1 (0.50) | CRHR1TDP1KHKMAP2K7ALDH1A1 | |
| SCHEMBL14276876 | 0.86 | CRHR1 (0.48) | CRHR1TDP1KHKMAP2K7 | |
| SCHEMBL13890636 | 0.86 | CRHR1 (0.50) | CRHR1TDP1MAP2K7KDM4EALDH1A1 | |
| SCHEMBL1638211 | 0.85 | CRHR1 (0.49) | CRHR1TDP1JAK2ABL1KDR | |
| SCHEMBL1637710 | 0.82 | CRHR1 (0.46) | CRHR1TDP1JAK2ABL1KDR | |
| SCHEMBL1637198 | 0.82 | CRHR1 (0.38) | CRHR1KHKKDM4EALDH1A1 | |
| SCHEMBL1636150 | 0.81 | CRHR1 (0.64) | CRHR1TDP1JAK2ABL1KDR | |
| SCHEMBL1636308 | 0.79 | CRHR1 (0.53) | CRHR1TDP1JAK2ABL1KDR | |
| SCHEMBL1638373 | 0.79 | CRHR1 (0.53) | CRHR1TDP1JAK2ABL1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1787992-B1 | Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with cyclic amino group | TAISHO PHARMACEUTICAL CO LTD (JP) | 2009-04-29 | — | — | EP | disclosed |