Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 5/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.53 |
| ▸ | ATR | Q13535 | 1/20 | 0.48 |
| ▸ | XDH | P47989 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29655604 | 1.00 | DHFR (0.59) | DHFRADORA1ADORA2AATRXDH | |
| SCHEMBL1388613 | 0.82 | DHFR (0.53) | DHFRKCNH2SCN10A | |
| SCHEMBL29655522 | 0.82 | DHFR (0.53) | DHFRKCNH2SCN10A | |
| SCHEMBL4457331 | 0.81 | ADORA2A (0.72) | DHFRADORA1ADORA2A | |
| SCHEMBL30488034 | 0.81 | ADORA2A (0.72) | DHFRADORA1ADORA2A | |
| SCHEMBL30046490 | 0.81 | KDM4E (0.54) | DHFRADORA1ADORA2AATRXDH | |
| SCHEMBL3412298 | 0.80 | DHFR (0.47) | DHFRADORA1ADORA2AATRXDH | |
| SCHEMBL29655536 | 0.78 | ADORA2A (0.72) | DHFRADORA1ADORA2AATR | |
| SCHEMBL1388662 | 0.78 | ADORA2A (0.72) | DHFRADORA1ADORA2AATR | |
| Hydrochloric Acid SCHEMBL27752359 | 0.77 | ADORA2A (0.71) | DHFRADORA1ADORA2AATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104203939-A | Diaminopyrimidines as human Respiratory Syncytial Virus (RSV) inhibitors | ABBVIE INC | 2014-12-10 | — | — | CN | claimed |
| JP-H08504798-A | — | — | 1996-05-21 | — | — | JP | claimed |
| WO-1994014780-A1 | PYRIMIDINE, PYRIDINE, PTERIDINONE AND INDAZOLE DERIVATIVES AS ENZYME INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-07-07 | — | — | WO | claimed |
| CN-112920124-B | Pyrimidine-2, 4-diamine compound, and preparation method and application thereof | 安徽医科大学 | 2024-03-01 | — | — | CN | disclosed |
| CN-111620852-B | 5-chloro-pyrimidine-2, 4-diamine compound, and preparation method and application thereof | 镇江植生源农业科技有限公司 | 2023-05-09 | — | — | CN | disclosed |
| CN-104203939-A | Diaminopyrimidines as human Respiratory Syncytial Virus (RSV) inhibitors | ABBVIE INC | 2014-12-10 | — | — | CN | disclosed |
| CN-101370792-B | Bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN INC | 2013-03-20 | — | — | CN | disclosed |
| CN-101506175-A | 2-anilino-4-(heterocyclic)amino-pyrimidines as inhibitors of protein kinase C-alpha | BOEHRINGER INGELHEIM INT (DE) | 2009-08-12 | — | — | CN | disclosed |
| CN-101370792-A | Bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN INC (US) | 2009-02-18 | — | — | CN | disclosed |
| WO-1994014780-A1 | PYRIMIDINE, PYRIDINE, PTERIDINONE AND INDAZOLE DERIVATIVES AS ENZYME INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-07-07 | — | — | WO | disclosed |