Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15753277 | 0.85 | PDE4D (0.55) | PDE4D | |
| SCHEMBL7320539 | 0.81 | PDE4B (0.47) | PDE4APDE4BPDE4DPDE4CCSNK2A1 | |
| SCHEMBL7380332 | 0.81 | PDE4A (0.53) | PDE4APDE4BPDE4DPDE4CCSNK2A1 | |
| SCHEMBL6889304 | 0.81 | PDE4A (0.63) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7374625 | 0.81 | PDE4A (0.52) | PDE4APDE4BPDE4DPDE4CCSNK2A1 | |
| Hydrochloric Acid SCHEMBL6887553 | 0.80 | PDE4A (0.62) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL984917 | 0.80 | PDE4D (0.57) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL6858739 | 0.80 | PDE4A (0.55) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL8436326 | 0.79 | PDE4A (0.60) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7360254 | 0.78 | PDE4D (0.54) | PDE4APDE4BPDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640065-B1 | TRISUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LTD (GB) | 2001-10-17 | — | — | EP | claimed |
| JP-H08505158-A | — | — | 1996-06-04 | — | — | JP | claimed |
| EP-0640065-A1 | TRISUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LIMITED (GB) | 1995-03-01 | — | — | EP | claimed |
| WO-1994020446-A1 | TRISUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LIMITED (GB) | 1994-09-15 | — | — | WO | claimed |
| EP-0640065-B1 | TRISUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LTD (GB) | 2001-10-17 | — | — | EP | disclosed |