Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1389102 | 0.81 | PDE4A (0.56) | PDE4APDE4BPDE4DPDE4CCSNK2A1 | |
| SCHEMBL7374625 | 0.79 | PDE4A (0.52) | PDE4APDE4BPDE4DPDE4CCSNK2A1 | |
| SCHEMBL5309679 | 0.75 | PDE4B (0.56) | PDE4APDE4BPDE4DPDE4CCSNK2A1 | |
| SCHEMBL984917 | 0.74 | PDE4D (0.57) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL6858739 | 0.74 | PDE4A (0.55) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL307931 | 0.73 | TPH1 (0.49) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL3976102 | 0.73 | PDE4B (0.57) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7380336 | 0.73 | PDE4B (0.64) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7320539 | 0.73 | PDE4B (0.47) | PDE4APDE4BPDE4DPDE4CCSNK2A1 | |
| SCHEMBL7387771 | 0.73 | PDE4A (0.54) | PDE4APDE4BPDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0796093-A4 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | EURO CELTIQUE SA (LU) | 1998-05-13 | — | — | EP | disclosed |
| EP-0796093-A1 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | Euroceltique S.A. (LU) | 1997-09-24 | — | — | EP | disclosed |
| WO-1996021435-A1 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | EURO-CELTIQUE, S.A. (LU) | 1996-07-18 | — | — | WO | disclosed |