Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8770151 | 1.00 | PDE4B (0.50) | PDE4BRECQLSMN1; SMN2HIF1AEGFR | |
| SCHEMBL1389104 | 1.00 | PDE4B (0.50) | PDE4BRECQLSMN1; SMN2HIF1AEGFR | |
| SCHEMBL1958419 | 0.87 | MAPT (0.56) | RECQLSMN1; SMN2HIF1AEGFRPDGFRB | |
| SCHEMBL1958420 | 0.87 | MAPT (0.56) | RECQLSMN1; SMN2HIF1AEGFRPDGFRB | |
| SCHEMBL1958418 | 0.87 | MAPT (0.56) | RECQLSMN1; SMN2HIF1AEGFRPDGFRB | |
| SCHEMBL8482808 | 0.84 | SMN1; SMN2 (0.57) | PDE4BRECQLSMN1; SMN2HIF1AEGFR | |
| SCHEMBL8482805 | 0.84 | SMN1; SMN2 (0.57) | PDE4BRECQLSMN1; SMN2HIF1AEGFR | |
| SCHEMBL6609676 | 0.83 | PDE4B (0.44) | PDE4BALDH1A1QRFPRPDE4APDE4C | |
| SCHEMBL6609672 | 0.83 | PDE4B (0.44) | PDE4BALDH1A1QRFPRPDE4APDE4C | |
| SCHEMBL7358568 | 0.82 | RECQL (0.57) | PDE4BRECQLSMN1; SMN2HIF1AEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640070-B1 | STYRYL DERIVATIVES, THEIR PREPARATION AND USE AS PDE-IV INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 1997-09-10 | — | — | EP | claimed |
| JP-H08501801-A | — | — | 1996-02-27 | — | — | JP | claimed |
| EP-0640070-A1 | STYRYL DERIVATIVES, THEIR PREPARATION AND USE AS PDE-IV INHIBITORS. | CELLTECH THERAPEUTICS LTD (GB) | 1995-03-01 | — | — | EP | claimed |
| WO-1994020455-A1 | STYRYL DERIVATIVES, THEIR PREPARATION AND USE AS PDE-IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1994-09-15 | — | — | WO | claimed |
| EP-0640070-B1 | STYRYL DERIVATIVES, THEIR PREPARATION AND USE AS PDE-IV INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 1997-09-10 | — | — | EP | disclosed |
| US-5633257-A | PHOSPHODIESTERASE INHIBITOR | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-05-27 | — | — | US | disclosed |