Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.44 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 14/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609676 | 1.00 | PDE4B (0.44) | PDE4BQRFPRPDE4APDE4DPDE4C | |
| SCHEMBL6609065 | 0.85 | MAPT (0.44) | PDE4BPDE4APDE4DPDE4CPDE5A | |
| SCHEMBL6609067 | 0.85 | MAPT (0.44) | PDE4BPDE4APDE4DPDE4CPDE5A | |
| SCHEMBL8770151 | 0.83 | PDE4B (0.50) | PDE4BQRFPRPDE4APDE4DPDE4C | |
| SCHEMBL1389103 | 0.83 | PDE4B (0.50) | PDE4BQRFPRPDE4APDE4DPDE4C | |
| SCHEMBL1389104 | 0.83 | PDE4B (0.50) | PDE4BQRFPRPDE4APDE4DPDE4C | |
| SCHEMBL6608648 | 0.81 | NPC1 (0.47) | PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL6608643 | 0.81 | NPC1 (0.47) | PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL6605351 | 0.80 | RECQL (0.54) | PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL6605357 | 0.80 | RECQL (0.54) | PDE4BPDE4APDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882714-B1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS PHARMACEUTICAL CO (JP) | 2004-03-03 | — | — | EP | disclosed |
| US-5935977-A | PHOSPHODIESTERASE IV INHIBITORS, TUMOR NECROSIS FACTOR-ALPHA PRODUCTION INHIBITORS; TREATING INFLAMMATORY AND AUTOIMMUNE DISEASES | SS PHARMACEUTICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0882714-A1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS Pharmaceutical Co., Ltd. (JP) | 1998-12-09 | — | — | EP | disclosed |