Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.71 |
| ▸ | POLB | P06746 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 7/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27599138 | 0.83 | NPC1 (0.77) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL31054249 | 0.83 | NPC1 (1.00) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL651929 | 0.83 | NPC1 (1.00) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL13609773 | 0.82 | NPC1 (0.68) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL4890353 | 0.81 | NPC1 (0.79) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL30741445 | 0.81 | NPC1 (0.79) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL7774453 | 0.80 | NPC1 (0.67) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL31084267 | 0.80 | NPC1 (0.67) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL4526983 | 0.80 | NPC1 (0.67) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL10310270 | 0.80 | NPC1 (0.67) | NPC1POLBMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020677-A9 | COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING | UNIV ROCHESTER (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009020677-A2 | COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING | UNIVERSITY OF ROCHESTER (US) | 2009-02-12 | — | — | WO | disclosed |