SCHEMBL651929

SCHEMBL651929

O=C(Nc1ccc2ncccc2c1)Nc1ccc2ncccc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 8/20 1.00
POLB P06746 3/20 1.00
MAPT P10636 2/20 1.00
MEN1 O00255 2/20 1.00
KMT2A Q03164 2/20 1.00
NAMPT P43490 2/20 0.72
PABPC1 P11940 1/20 0.70
RAB9A P51151 7/20 0.65
ALDH1A1 P00352 2/20 0.62
CASP3 P42574 1/20 0.62
SENP8 Q96LD8 1/20 0.62
SENP7 Q9BQF6 1/20 0.62
SENP6 Q9GZR1 1/20 0.62
CYP1A2 P05177 1/20 0.62
CYP3A4 P08684 1/20 0.62
TSHR P16473 1/20 0.62
HSD17B10 Q99714 1/20 0.62
CCNE1 P24864 1/20 0.62
CDK2 P24941 1/20 0.62
CDK5 Q00535 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31054249 1.00 NPC1 (1.00) NPC1POLBMAPTMEN1KMT2A
SCHEMBL5655823 0.94 NPC1 (0.88) NPC1POLBMAPTMEN1KMT2A
SCHEMBL5658310 0.94 NPC1 (0.88) NPC1POLBMAPTMEN1KMT2A
SCHEMBL29639124 0.90 NPC1 (0.81) NPC1POLBMAPTMEN1KMT2A
SCHEMBL5661569 0.90 NPC1 (0.81) NPC1POLBMAPTMEN1KMT2A
SCHEMBL28741230 0.90 NPC1 (0.81) NPC1POLBMAPTMEN1KMT2A
SCHEMBL5657576 0.89 NPC1 (0.78) NPC1POLBMAPTMEN1KMT2A
SCHEMBL5658555 0.89 NPC1 (0.78) NPC1POLBMAPTMEN1KMT2A
SCHEMBL30741445 0.88 NPC1 (0.79) NPC1POLBMAPTMEN1KMT2A
SCHEMBL4890353 0.88 NPC1 (0.79) NPC1POLBMAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 399 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4731204-A2 SELECTIVE RBP4 ANTAGONIST AND C20-D3-RETINOL FOR TREATING MACULAR DEGENERATION, NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD), AND GOUTY ARTHRITIS (GOUT) The Trustees Of Columbia University In The City Of New York (US) 2026-04-29 EP claimed
EP-4731619-A2 NOVEL CO-DRUG, CO-ADMINISTRATION, AND SEQUENTIAL ADMINISTRATION OF BISPECIFIC RBP4/TTR LIGAND AND C20-D3-RETINOL The Trustees Of Columbia University In The City Of New York (US) 2026-04-29 EP claimed
EP-4731618-A2 NOVEL CO-DRUG, CO-ADMINISTRATION, AND SEQUENTIAL ADMINISTRATION OF SELECTIVE TTR LIGAND AND C20-D3-RETINOL The Trustees Of Columbia University In The City Of New York (US) 2026-04-29 EP claimed
US-20250387433-A1 COMPOSITION FOR PREVENTING OR TREATING RETINAL DEGENERATIVE DISEASE CONTAINING EXOSOMES EXTRACTED FROM MESENCHYMAL STEM CELLS SEOUL NATIONAL UNIVERSITY HOSPITAL (KR) 2025-12-25 US claimed
US-12473302-B2 4-phenylpiperidines, their preparation and use THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2025-11-18 US claimed
US-20250320218-A1 SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2025-10-16 US claimed
WO-2024263751-A2 NOVEL CO-DRUG, CO-ADMINISTRATION, AND SEQUENTIAL ADMINISTRATION OF SELECTIVE TTR LIGAND AND C20-D3-RETINOL FOR ELIMINATION OF MECHANISM-BASED OCULAR ADVERSE EFFECTS IN TREATING MACULAR DEGENERATION AND TTR AMYLOIDOSIS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2024-12-26 WO claimed
WO-2024263790-A2 NOVEL CO-DRUG, CO-ADMINISTRATION, AND SEQUENTIAL ADMINISTRATION OF SELECTIVE RBP4 ANTAGONIST AND C20-D3-RETINOL FOR ELIMINATION OF MECHANISM-BASED OCULAR ADVERSE EFFECTS IN TREATING MACULAR DEGENERATION, NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD), AND GOUTY ARTHRITIS (GOUT) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2024-12-26 WO claimed
WO-2024263782-A2 NOVEL CO-DRUG, CO-ADMINISTRATION, AND SEQUENTIAL ADMINISTRATION OF BISPECIFIC RBP4/TTR LIGAND AND C20-D3-RETINOL FOR ELIMINATION OF MECHANISM-BASED OCULAR ADVERSE EFFECTS IN TREATING MACULAR DEGENERATION AND TTR AMYLOIDOSIS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2024-12-26 WO claimed
US-12168664-B2 Triazolopyrimidines, their preparation and use THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2024-12-17 US claimed
US-20030225268-A1 Diazabicyclic CNS active agents ABBVIE INC. 2003-12-04 US claimed
US-6656958-B2 Preferred compounds are 3'-(5'- and/or 6'-substituted) pyridyl ethers; selectively controlling neurotransmitter release in mammals using these compounds ABBOTT LABORATORIES 2003-12-02 US claimed
EP-1359152-A2 Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands ABBOTT LABORATORIES (US) 2003-11-05 EP claimed
EP-1147112-B1 DIAZABICYCLIC DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS ABBOTT LAB (US) 2003-10-29 EP claimed
US-6477416-B1 System and method for automatically and adaptively segmenting an atrial blanking period PACESETTER, INC. 2002-11-05 US claimed
JP-2002535409-A 2002-10-22 JP claimed
US-6327499-B1 Cardiac stimulator and defibrillator ADVANCED MEDICAL DEVICES, S.A. (LU) 2001-12-04 US claimed
EP-1147112-A1 DIAZABICYCLIC DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS ABBOTT LABORATORIES (US) 2001-10-24 EP claimed
WO-2000044755-A1 DIAZABICYCLIC DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS ABBOTT LABORATORIES (US) 2000-08-03 WO claimed
CN-1063686-A With the synthetic vesnarinone of active ester method MEDICINE INST HUAXI MEDICAL UN (CN) 1992-08-19 CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12168664-B2 Triazolopyrimidines, their preparation and use ABL1, CBR3, DPYD NPC1 3520/4885POLB 2030/4885MAPT 4406/4885
US-12473302-B2 4-phenylpiperidines, their preparation and use HTR3C, HRH4, DRD3 NPC1 3005/4885POLB 3536/4885MAPT 3601/4885
US-20250387433-A1 COMPOSITION FOR PREVENTING OR TREATING RETINAL DEGENERATIVE DISEASE CONTAINING EXOSOMES EXTRACTED FROM MESENCHYMAL STEM CELLS EXOSC9, EXOSC5, MTREX NPC1 968/4885POLB 4325/4885MAPT 175/4885
US-20030225268-A1 Diazabicyclic CNS active agents GABRE, GRIN1, CNTN1 NPC1 440/4885POLB 4480/4885MAPT 2125/4885
US-20250320218-A1 SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE HRH4, HRH3, HRH2 NPC1 1790/4885POLB 3378/4885MAPT 4510/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.