Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPO1 | O14980 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.45 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.45 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13892296 | 0.83 | SMN1; SMN2 (0.54) | XPO1SMN1; SMN2LMNACYP1A2KMT2A | |
| SCHEMBL12377871 | 0.82 | TRPM8 (0.62) | XPO1SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL13947396 | 0.82 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNARAB9AL3MBTL1TRPM8 | |
| SCHEMBL5740158 | 0.81 | XPO1 (0.47) | XPO1SMN1; SMN2MEN1CYP1A2CYP2C9 | |
| SCHEMBL13947009 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNARAB9AL3MBTL1TRPM8 | |
| SCHEMBL8205448 | 0.80 | XPO1 (0.48) | XPO1SMN1; SMN2MEN1CYP1A2CYP2C9 | |
| SCHEMBL13880158 | 0.79 | AAK1 (0.47) | XPO1CYP2C9RAB9ANPC1IDO1 | |
| SCHEMBL2619292 | 0.79 | SMN1; SMN2 (0.68) | SMN1; SMN2LMNAMEN1CYP1A2CYP2C19 | |
| SCHEMBL10734442 | 0.79 | XPO1 (0.48) | XPO1SMN1; SMN2MAOBRAB9AL3MBTL1 | |
| SCHEMBL15554936 | 0.79 | XPO1 (0.43) | XPO1SMN1; SMN2LMNAMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090098085-A1 | TETRAZOLYL ACYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | disclosed |
| US-20090035268-A1 | TETRAZOLYL ACYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090098085-A1 | TETRAZOLYL ACYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | TMPRSS4, PRSS1, SPINT2 | XPO1 2852/4885SMN1; SMN2 3971/4885LMNA 3337/4885 |
| US-20090035268-A1 | TETRAZOLYL ACYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | TMPRSS4, PRSS1, SPINT2 | XPO1 2852/4885SMN1; SMN2 3971/4885LMNA 3337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.