Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14606319 | 0.91 | CTSB (0.39) | CTSBCTSSCYP3A4ADRB3ADRA2B | |
| SCHEMBL13082459 | 0.89 | CYP3A4 (0.40) | CTSBCTSSCYP3A4ADRB3ADRA2B | |
| SCHEMBL13945568 | 0.89 | CTSB (0.39) | CTSBCTSSCYP3A4ADRB3ADRA2B | |
| SCHEMBL13564279 | 0.89 | CTSB (0.38) | CTSBCTSSCYP3A4ADRB3ADRA2B | |
| SCHEMBL13788186 | 0.89 | CTSB (0.38) | CTSBCTSSCYP3A4ADRB3ADRA2B | |
| SCHEMBL13824946 | 0.89 | CTSB (0.38) | CTSBCTSSCYP3A4ADRB3ADRA2B | |
| SCHEMBL13946860 | 0.88 | ADRB3 (0.42) | CYP3A4ADRB3ADRA2BADRA2C | |
| SCHEMBL13788164 | 0.87 | CTSB (0.38) | CTSBCTSSCYP3A4ADRB3ADRA2B | |
| SCHEMBL13788185 | 0.87 | CTSB (0.37) | CTSBCTSSCYP3A4ADRB3ADRA2B | |
| SCHEMBL8279923 | 0.85 | CTSB (0.40) | CTSBCTSSCYP3A4ADRB3ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090111969-A1 | MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION | HOFFMANN-LA ROCHE INC. | 2009-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111969-A1 | MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION | EIF2AK2, HAVCR2, ZC3HAV1 | CTSB 1317/4885CTSS 1471/4885CYP3A4 281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.