Fiacitabine

Fiacitabine

SCHEMBL138934

Nc1nc(=O)n([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2F)cc1I

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE2A O00408 1/20 0.50
ADORA3 P0DMS8 1/20 0.50
ADORA2A P29274 1/20 0.50
ADORA1 P30542 1/20 0.50
ADRA1A P35348 1/20 0.50
PDE4D Q08499 1/20 0.50
PDE3A Q14432 1/20 0.50
LMNA P02545 3/20 0.49
MTOR P42345 2/20 0.49
ALDH1A1 P00352 2/20 0.49
THRB P10828 1/20 0.49
MDM2 Q00987 1/20 0.49
NCOA1 Q15788 1/20 0.49
NCOA3 Q9Y6Q9 1/20 0.49
GMNN O75496 1/20 0.49
TP53 P04637 1/20 0.49
NFKB1 P19838 1/20 0.49
DNMT1 P26358 1/20 0.49
THPO P40225 1/20 0.49
HTT P42858 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fiacitabine SCHEMBL6715038 1.00 PDE2A (0.50) PDE2AADORA3ADORA2AADORA1ADRA1A
Fiacitabine SCHEMBL6725815 1.00 PDE2A (0.50) PDE2AADORA3ADORA2AADORA1ADRA1A
Fiacitabine SCHEMBL138935 1.00 PDE2A (0.50) PDE2AADORA3ADORA2AADORA1ADRA1A
Fiacitabine SCHEMBL773659 1.00 PDE2A (0.50) PDE2AADORA3ADORA2AADORA1ADRA1A
Fiacitabine SCHEMBL3120689 1.00 PDE2A (0.50) PDE2AADORA3ADORA2AADORA1ADRA1A
Fiacitabine SCHEMBL15630217 1.00 PDE2A (0.50) PDE2AADORA3ADORA2AADORA1ADRA1A
Fiacitabine SCHEMBL16943181 1.00 PDE2A (0.50) PDE2AADORA3ADORA2AADORA1ADRA1A
Fiacitabine SCHEMBL1984820 1.00 PDE2A (0.50) PDE2AADORA3ADORA2AADORA1ADRA1A
Fiacitabine SCHEMBL768016 1.00 PDE2A (0.50) PDE2AADORA3ADORA2AADORA1ADRA1A
Fiacitabine SCHEMBL7464079 1.00 PDE2A (0.50) PDE2AADORA3ADORA2AADORA1ADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1999 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2026-05-28 US claimed
WO-2026043843-A1 TETRAHYDROPYRIMIDINE (THP) IONIZABLE LIPIDS FOR EFFICIENT MRNA DELIVERY THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, (US) 2026-02-26 WO claimed
WO-2025076059-A1 ROCAGLATE DERIVATIVES AND USES THEREOF TRUSTEES OF BOSTON UNIVERSITY (US) 2025-04-10 WO claimed
WO-2024215771-A1 SUBSTITUTED PHENYL ETHYNYL PYRIMIDINES AS POTENT INHIBITORS OF ALPHAVIRUSES SOUTHERN RESEARCH INSTITUTE (US) 2024-10-17 WO claimed
CN-115834293-B Building private network construction method and building private network 中国联合网络通信集团有限公司 2024-07-19 CN claimed
US-20240139325-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2024-05-02 US claimed
CN-117915401-A Task unloading and resource allocation method for edge computing system in WiFi-cellular heterogeneous network 北京邮电大学 2024-04-19 CN claimed
EP-4262812-A1 6-AZA-NUCLEOSIDE PRODRUGS AS ANTIVIRAL AGENTS FOR TREATING VIRUS INFECTIONS Southern Research Institute (US) 2023-10-25 EP claimed
CN-116450572-A Power supply chain data storage optimization method and system based on block chain 国网辽宁省电力有限公司信息通信分公司 2023-07-18 CN claimed
WO-2023122212-A2 SUBSTITUTED PHENYL ETHYNYL PYRIDINE CARBOXAMIDES AS POTENT INHIBITORS OF SARS VIRUS SOUTHERN RESEARCH INSTITUTE (US) 2023-06-29 WO claimed
EP-0618226-A1 Inhibitors of herpes viral ribonculeotide reductase BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1994-10-05 EP claimed
WO-1994020528-A1 INHIBITORS OF HERPES VIRAL RIBONUCLEOTIDE REDUCTASE BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1994-09-15 WO claimed
WO-1993018056-A1 ISOSTERIC ANTIHERPES PEPTIDE DERIVATIVES BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1993-09-16 WO claimed
EP-0560274-A1 Antiherpes peptide derivatives having a ureido N-terminus BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1993-09-15 EP claimed
EP-0560267-A1 Isosteric antiherpes peptide derivatives BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1993-09-15 EP claimed
EP-0493770-A2 Antiherpes compositions BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1992-07-08 EP claimed
EP-0493767-A2 Synergistic combination for treating herpes infections BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1992-07-08 EP claimed
EP-0010205-B1 5-SUBSTITUTED 1-(2'-DEOXY-2'-SUBSTITUTED-BETA-D-ARABINOFURANOSYL) PYRIMIDINE NUCLEOSIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Sloan-Kettering Institute For Cancer Research (US) 1983-05-04 EP claimed
US-4211773-A VIRICIDES, ANTITUMOR AGENTS SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1980-07-08 US claimed
EP-0010205-A1 5-Substituted 1-(2'-deoxy-2'-substituted-beta-D-arabinofuranosyl) pyrimidine nucleosides and pharmaceutical compositions containing them Sloan-Kettering Institute For Cancer Research (US) 1980-04-30 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS HAVCR2, NR1H4, NR1H3 PDE2A 4801/4885ADORA3 558/4885ADORA2A 1902/4885
US-20240139325-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS SLC10A1, HAVCR2, HDGF PDE2A 4804/4885ADORA3 3777/4885ADORA2A 4586/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.