Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8227574 | 0.81 | HPGD (0.44) | KMT2AGAAMAPK1MAPTHTT | |
| SCHEMBL18752314 | 0.81 | KDM4E (0.45) | KMT2ALMNAMEN1RAB9AALDH1A1 | |
| SCHEMBL4660757 | 0.80 | GAA (0.50) | KMT2AGAAMAPK1MAPTHTT | |
| Hydrochloric Acid SCHEMBL11289102 | 0.76 | AOC3 (0.47) | KMT2AGAAMAPK1MAPTHTT | |
| SCHEMBL8976610 | 0.74 | KMT2A (0.62) | KMT2AGAAMAPK1MAPTHTT | |
| SCHEMBL13749957 | 0.72 | KMT2A (0.49) | KMT2AGAAMAPK1MAPTHTT | |
| SCHEMBL21586952 | 0.71 | ESRRA (0.44) | GAAMAPTHTTPOLBLMNA | |
| SCHEMBL9124010 | 0.71 | KMT2A (0.51) | KMT2AGAAMAPK1MAPTHTT | |
| SCHEMBL9124005 | 0.71 | KMT2A (0.51) | KMT2AGAAMAPK1MAPTHTT | |
| SCHEMBL20053879 | 0.71 | ALDH1A1 (0.45) | KMT2AGAAMAPTPOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2053041-A2 | 1,3,5-Trisubstituted 2(1H)-pyridones as AMPA receptor inhibitors useful for the treatment of eg Parkinson's disease | Eisai R&D Management Co., Ltd. (JP) | 2009-04-29 | — | — | EP | disclosed |