Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.44 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 5/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | CPT2 | P23786 | 1/20 | 0.35 |
| ▸ | CPT1A | P50416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13893939 | 0.91 | PRKD1 (0.41) | NAMPTPRKD1KDM4ELMNAPOLB | |
| SCHEMBL13893937 | 0.90 | PRKD1 (0.48) | PRKD1ROCK1KDM4ELMNAPOLB | |
| SCHEMBL13893896 | 0.88 | MAPT (0.41) | PRKD1KDM4ELMNAPOLBJAK2 | |
| SCHEMBL13893942 | 0.84 | ROCK1 (0.43) | NAMPTROCK1ROCK2TYK2 | |
| SCHEMBL13893895 | 0.83 | KDM4E (0.41) | PRKD1KDM4ELMNAPOLBFYN | |
| SCHEMBL13893934 | 0.83 | KDM4E (0.47) | PRKD1KDM4ELMNAPOLBFYN | |
| SCHEMBL13893946 | 0.79 | KDM4E (0.38) | PRKD1KDM4ELMNAPOLBFYN | |
| SCHEMBL13894014 | 0.72 | BTK (0.46) | NAMPTPRKD1KDM4ELMNAPOLB | |
| SCHEMBL13893953 | 0.71 | NR1H4 (0.39) | PRKD1KDM4ELMNAPOLBJAK2 | |
| SCHEMBL104011 | 0.71 | BTK (0.52) | KDM4ETYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009053269-A1 | NOVEL KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-30 | — | — | WO | disclosed |