Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13893939 | 0.93 | PRKD1 (0.41) | PRKD1KDM4ELMNAPOLBPARP1 | |
| SCHEMBL13893896 | 0.91 | MAPT (0.41) | PRKD1KDM4ELMNAPOLBPARP1 | |
| SCHEMBL13893898 | 0.90 | NAMPT (0.44) | PRKD1KDM4ELMNAPOLBTYK2 | |
| SCHEMBL13893895 | 0.84 | KDM4E (0.41) | PRKD1KDM4ELMNAPOLBTYK2 | |
| SCHEMBL13893934 | 0.84 | KDM4E (0.47) | PRKD1KDM4ELMNAPOLBPARP1 | |
| SCHEMBL13894014 | 0.80 | BTK (0.46) | PRKD1KDM4ELMNAPOLBTYK2 | |
| SCHEMBL13893946 | 0.80 | KDM4E (0.38) | PRKD1KDM4ELMNAPOLBTYK2 | |
| SCHEMBL13893942 | 0.77 | ROCK1 (0.43) | PARP1TYK2ROCK1 | |
| SCHEMBL12602921 | 0.73 | BTK (0.53) | KDM4ETYK2BTK | |
| SCHEMBL13893953 | 0.72 | NR1H4 (0.39) | PRKD1KDM4ELMNAPOLBPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009053269-A1 | NOVEL KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-30 | — | — | WO | disclosed |