SCHEMBL13893948

SCHEMBL13893948

CSc1nccc(Nc2cc(-c3cccc(NC(=O)c4ccc(C(C)(C)C)cc4)c3C)n[nH]c2=O)n1

nearest known ligand 0.54

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BTK Q06187 18/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13894041 0.87 BTK (0.54) BTK
SCHEMBL103940 0.85 BTK (0.48) BTK
SCHEMBL13894044 0.85 BTK (0.51) BTK
SCHEMBL13893944 0.83 BTK (0.53) BTK
SCHEMBL13894047 0.83 BTK (0.47) BTK
SCHEMBL13893941 0.83 BTK (0.55) BTK
SCHEMBL13894053 0.80 BTK (0.45) BTK
SCHEMBL13894042 0.80 BTK (0.44) BTK
SCHEMBL13893894 0.77 BTK (0.45) BTK
SCHEMBL13893893 0.77 BTK (0.48) BTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009053269-A1 NOVEL KINASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2009-04-30 WO disclosed