Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.41 |
| ▸ | ITK | Q08881 | 14/20 | 0.41 |
| ▸ | FLT3 | P36888 | 8/20 | 0.38 |
| ▸ | SRC | P12931 | 7/20 | 0.38 |
| ▸ | KIT | P10721 | 6/20 | 0.38 |
| ▸ | TTK | P33981 | 4/20 | 0.38 |
| ▸ | AURKA | O14965 | 3/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.38 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13894013 | 0.85 | BTK (0.56) | BTKITKFLT3SRCKIT | |
| SCHEMBL13894022 | 0.85 | ITK (0.49) | BTKITKFLT3SRCKIT | |
| SCHEMBL13894122 | 0.85 | ITK (0.54) | BTKITKFLT3SRCKIT | |
| SCHEMBL3868663 | 0.85 | BTK (0.60) | BTKCLK2 | |
| SCHEMBL13894054 | 0.82 | CLK2 (0.42) | BTKITKFLT3SRCKIT | |
| SCHEMBL13894040 | 0.80 | BTK (0.44) | BTKITKFLT3SRCKIT | |
| SCHEMBL13893960 | 0.80 | BTK (0.43) | BTKITKFLT3SRCKIT | |
| SCHEMBL3874728 | 0.75 | BTK (0.61) | BTKCLK2 | |
| SCHEMBL3870962 | 0.75 | BTK (0.70) | BTKITKFLT3SRCKIT | |
| SCHEMBL108327 | 0.69 | BTK (0.81) | BTKCLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009053269-A1 | NOVEL KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-30 | — | — | WO | disclosed |