Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 10/20 | 0.54 |
| ▸ | KIT | P10721 | 4/20 | 0.54 |
| ▸ | SRC | P12931 | 4/20 | 0.54 |
| ▸ | FLT3 | P36888 | 4/20 | 0.54 |
| ▸ | BTK | Q06187 | 4/20 | 0.44 |
| ▸ | TTK | P33981 | 3/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13894013 | 0.89 | BTK (0.56) | ITKKITSRCFLT3BTK | |
| SCHEMBL13894022 | 0.86 | ITK (0.49) | ITKKITSRCFLT3BTK | |
| SCHEMBL13894050 | 0.85 | BTK (0.41) | ITKKITSRCFLT3BTK | |
| SCHEMBL3874826 | 0.83 | BTK (0.64) | BTK | |
| SCHEMBL13894117 | 0.81 | ITK (0.53) | ITKKITSRCFLT3BTK | |
| SCHEMBL13894038 | 0.79 | ITK (0.47) | ITKKITSRCFLT3BTK | |
| SCHEMBL13894290 | 0.79 | ITK (0.58) | ITKKITSRCFLT3BTK | |
| SCHEMBL3870962 | 0.78 | BTK (0.70) | ITKKITSRCFLT3BTK | |
| SCHEMBL13894111 | 0.73 | BTK (0.53) | ITKKITSRCFLT3BTK | |
| SCHEMBL13894036 | 0.73 | ITK (0.54) | ITKKITSRCFLT3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009053269-A1 | NOVEL KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-30 | — | — | WO | disclosed |