SCHEMBL13894584

SCHEMBL13894584

C=C1C(Cl)=C(/C=C(\C)C(=O)O)C(=O)c2ccccc21

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APEX1 P27695 14/20 0.78
AKR1C3 P42330 1/20 0.44
HSP90AA1 P07900 1/20 0.40
HSP90AB1 P08238 1/20 0.40
IDO1 P14902 1/20 0.38
DNMT1 P26358 1/20 0.38
DNMT3L Q9UJW3 1/20 0.38
DNMT3A Q9Y6K1 1/20 0.38
PTPN6 P29350 1/20 0.36
ALDH1A1 P00352 1/20 0.36
MAPT P10636 1/20 0.36
HTT P42858 1/20 0.36
RAB9A P51151 1/20 0.36
ATM Q13315 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
MEN1 O00255 1/20 0.36
APAF1 O14727 1/20 0.36
TDP2 O95551 1/20 0.36
NSD2 O96028 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13894618 1.00 APEX1 (0.78) APEX1AKR1C3HSP90AA1HSP90AB1IDO1
SCHEMBL3743461 0.88 APEX1 (1.00) APEX1AKR1C3HSP90AA1HSP90AB1IDO1
SCHEMBL3743465 0.88 APEX1 (1.00) APEX1AKR1C3HSP90AA1HSP90AB1IDO1
SCHEMBL3745788 0.88 APEX1 (1.00) APEX1AKR1C3HSP90AA1HSP90AB1IDO1
SCHEMBL13894615 0.85 APEX1 (0.57) APEX1HSP90AA1HSP90AB1PTPN6ALDH1A1
SCHEMBL13894583 0.84 APEX1 (0.78) APEX1AKR1C3ALDH1A1MAPTHTT
SCHEMBL20123280 0.83 APEX1 (0.78) APEX1AKR1C3HSP90AA1HSP90AB1IDO1
SCHEMBL13894619 0.83 APEX1 (0.67) APEX1AKR1C3HSP90AA1HSP90AB1MAPT
SCHEMBL13894616 0.81 APEX1 (0.84) APEX1HSP90AA1HSP90AB1ALDH1A1MAPT
SCHEMBL13894609 0.78 APEX1 (0.75) APEX1HSP90AA1HSP90AB1IDO1DNMT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009042544-A1 QUINONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2009-04-02 WO disclosed