Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13895019 | 0.88 | MCHR1 (0.43) | MCHR1MTORL3MBTL1DGAT1KCNH2 | |
| SCHEMBL13894788 | 0.86 | MCHR1 (0.43) | RAB9AMCHR1MTORDGAT1KCNH2 | |
| SCHEMBL13895117 | 0.85 | MCHR1 (0.49) | SMN1; SMN2RAB9ANPC1MCHR1MTOR | |
| SCHEMBL13887396 | 0.84 | MCHR1 (0.60) | GAAHTTAHRSMN1; SMN2RAB9A | |
| SCHEMBL13894953 | 0.84 | MCHR1 (0.44) | MCHR1HTR6CYP3A4 | |
| SCHEMBL13894787 | 0.84 | MCHR1 (0.51) | GAAHTTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL13894952 | 0.83 | MCHR1 (0.42) | MCHR1MTORDGAT1KCNH2 | |
| SCHEMBL13894933 | 0.83 | MCHR1 (0.42) | MCHR1MTORL3MBTL1DGAT1KCNH2 | |
| SCHEMBL13894951 | 0.82 | MCHR1 (0.41) | MCHR1MTORMAPTDGAT1KCNH2 | |
| SCHEMBL13895113 | 0.82 | ALDH1A1 (0.44) | GAASMN1; SMN2RAB9ANPC1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524862-B2 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-28 | — | — | US | disclosed |