Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 8/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.45 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13895002 | 0.88 | TRPC3 (0.48) | LMNADGAT1KCNH2TRPC3MAPT | |
| SCHEMBL13894936 | 0.85 | TRPC3 (0.61) | LMNADGAT1KCNH2TRPC3MAPT | |
| SCHEMBL13887301 | 0.84 | MCHR1 (0.57) | LMNATRPC3MAPTTP53MCHR1 | |
| SCHEMBL13894921 | 0.84 | GFER (0.56) | DGAT1KCNH2TRPC3MAPTTP53 | |
| SCHEMBL13894864 | 0.84 | GFER (0.53) | DGAT1KCNH2TRPC3TP53RAB9A | |
| SCHEMBL13895105 | 0.83 | TRPC3 (0.43) | LMNADGAT1KCNH2TRPC3TP53 | |
| SCHEMBL13894938 | 0.83 | GFER (0.58) | LMNADGAT1KCNH2TRPC3MAPT | |
| SCHEMBL13895003 | 0.83 | TRPC3 (0.45) | LMNADGAT1KCNH2TRPC3MAPT | |
| SCHEMBL13894780 | 0.81 | TP53 (0.49) | DGAT1KCNH2TRPC3TP53RAB9A | |
| SCHEMBL13894880 | 0.80 | GAA (0.46) | DGAT1KCNH2MAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524862-B2 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-28 | — | — | US | disclosed |