Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.54 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.52 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.52 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.49 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.49 |
| ▸ | FECH | P22830 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.48 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2990157 | 0.89 | EGFR (0.62) | EGFRERBB2LMNAMAPTHTT | |
| SCHEMBL4866251 | 0.88 | EGFR (0.67) | EGFRERBB2ERBB4ERBB3FECH | |
| SCHEMBL5786020 | 0.85 | ERBB2 (0.51) | EGFRERBB2ERBB4ERBB3TTBK1 | |
| SCHEMBL29888026 | 0.85 | ERBB2 (0.51) | EGFRERBB2ERBB4ERBB3TTBK1 | |
| SCHEMBL24569470 | 0.85 | ERBB2 (0.51) | EGFRERBB2ERBB4ERBB3TTBK1 | |
| SCHEMBL6483391 | 0.85 | ERBB2 (0.49) | EGFRERBB2ERBB4ERBB3TTBK1 | |
| SCHEMBL6176588 | 0.85 | ERBB2 (0.59) | EGFRERBB2ERBB4ERBB3TTBK1 | |
| SCHEMBL5081054 | 0.85 | ERBB2 (0.53) | EGFRERBB2ERBB4ERBB3TTBK1 | |
| SCHEMBL5081050 | 0.84 | ERBB2 (0.52) | EGFRERBB2ERBB4ERBB3FECH | |
| SCHEMBL4617501 | 0.84 | EGFR (0.60) | EGFRERBB2ERBB4ERBB3TTBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660090-B1 | QUINAZOLINE ANALOGS AS RECEPTOR TYROSINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2012-11-21 | — | — | EP | disclosed |