Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 11/20 | 0.49 |
| ▸ | EGFR | P00533 | 8/20 | 0.47 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.47 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.47 |
| ▸ | FECH | P22830 | 2/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.45 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | MYH14 | Q7Z406 | 1/20 | 0.43 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.43 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.43 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6487993 | 0.89 | EGFR (0.51) | ERBB2EGFRERBB4ERBB3FLT1 | |
| SCHEMBL5078469 | 0.89 | ERBB2 (0.60) | ERBB2EGFRERBB4ERBB3FECH | |
| SCHEMBL5081054 | 0.89 | ERBB2 (0.53) | ERBB2EGFRERBB4ERBB3FECH | |
| SCHEMBL4619108 | 0.89 | ERBB2 (0.55) | ERBB2EGFRERBB4ERBB3FECH | |
| SCHEMBL6173008 | 0.88 | ERBB2 (0.56) | ERBB2EGFRERBB4ERBB3FECH | |
| SCHEMBL6189061 | 0.88 | EGFR (0.56) | ERBB2EGFRERBB4ERBB3FECH | |
| SCHEMBL5081050 | 0.88 | ERBB2 (0.52) | ERBB2EGFRERBB4ERBB3FECH | |
| SCHEMBL6176629 | 0.87 | ERBB2 (0.52) | ERBB2EGFRERBB4ERBB3FECH | |
| SCHEMBL6175648 | 0.87 | EGFR (0.55) | ERBB2EGFRERBB4ERBB3FECH | |
| SCHEMBL6175257 | 0.87 | ERBB2 (0.56) | ERBB2EGFRERBB4ERBB3FECH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890924-B2 | Substituted bicyclic derivatives for the treatment of abnormal cell growth | PFIZER INC (US) | 2005-05-10 | — | — | US | disclosed |