Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 4/20 | 0.32 |
| ▸ | CA1 | P00915 | 4/20 | 0.32 |
| ▸ | CA9 | Q16790 | 4/20 | 0.32 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474104 | 0.85 | PREP (0.40) | PREPHTTALDH1A1LMNACA12 | |
| SCHEMBL474105 | 0.85 | PREP (0.40) | PREPHTTALDH1A1LMNACA12 | |
| SCHEMBL4909924 | 0.85 | PREP (0.40) | PREPHTTALDH1A1LMNACA12 | |
| SCHEMBL1508406 | 0.75 | PREP (0.42) | PREPHTTALDH1A1LMNACA12 | |
| SCHEMBL13899358 | 0.74 | PREP (0.38) | PREPCA12CA1CA9NPSR1 | |
| SCHEMBL7237737 | 0.74 | PREP (0.41) | PREPHTTALDH1A1LMNACA12 | |
| SCHEMBL7455145 | 0.74 | PREP (0.41) | PREPHTTALDH1A1LMNACA12 | |
| SCHEMBL13899285 | 0.73 | AAK1 (0.49) | LMNAKMT2A | |
| SCHEMBL10827924 | 0.72 | PREP (0.42) | PREPCA12CA1CA9NPSR1 | |
| SCHEMBL13899562 | 0.72 | PREP (0.34) | PREPCYP1A2CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507757-B2 | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-03-24 | — | — | US | disclosed |