Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 7/20 | 0.38 |
| ▸ | FNTB | P49356 | 7/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PGGT1B | P53609 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13501471 | 0.87 | FNTA (0.38) | FNTAFNTBKMT2AMEN1RXFP1 | |
| SCHEMBL4372579 | 0.64 | FNTA (0.49) | FNTAFNTBPGGT1BMDM2 | |
| SCHEMBL13501593 | 0.63 | MEN1 (0.32) | KMT2AMEN1RXFP1MAPTLMNA | |
| SCHEMBL4377464 | 0.62 | FNTA (0.45) | FNTAFNTB | |
| SCHEMBL4371953 | 0.62 | FNTA (0.47) | FNTAFNTBKMT2AMEN1MAPT | |
| SCHEMBL4382960 | 0.59 | FNTA (0.52) | FNTAFNTBMAPTPGGT1B | |
| SCHEMBL11954827 | 0.58 | FNTA (0.82) | FNTAFNTBPGGT1B | |
| SCHEMBL7186370 | 0.57 | FNTA (0.45) | FNTAFNTBFFAR1 | |
| SCHEMBL4378944 | 0.57 | FNTA (0.49) | FNTAFNTBPGGT1B | |
| SCHEMBL5778239 | 0.56 | FNTA (0.68) | FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511138-B2 | Farnesyl transferase inhibiting tricyclic quinazoline derivatives substituted with carbon-linked imidazoles or triazoles | JANSSEN PHARMACEUTICA NV (BE) | 2009-03-31 | — | — | US | disclosed |