Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 7/20 | 0.49 |
| ▸ | FNTB | P49356 | 7/20 | 0.49 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4374148 | 0.80 | FNTA (0.63) | FNTAFNTBPGGT1B | |
| SCHEMBL4382829 | 0.79 | FNTA (0.62) | FNTAFNTBPGGT1B | |
| SCHEMBL4376761 | 0.79 | FNTA (0.43) | FNTAFNTBMDM2IDO1 | |
| SCHEMBL4377464 | 0.79 | FNTA (0.45) | FNTAFNTB | |
| SCHEMBL4371953 | 0.79 | FNTA (0.47) | FNTAFNTBPGGT1BMDM2 | |
| SCHEMBL4372100 | 0.76 | FNTA (0.46) | FNTAFNTBPGGT1BMDM2 | |
| SCHEMBL4377044 | 0.74 | FNTA (0.42) | FNTAFNTBMDM2 | |
| SCHEMBL5562152 | 0.74 | FNTA (0.52) | FNTAFNTBPGGT1BMDM2IDO1 | |
| SCHEMBL4370606 | 0.71 | FNTA (0.46) | FNTAFNTB | |
| SCHEMBL2181595 | 0.71 | FNTA (0.36) | FNTAFNTBPGGT1BIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339709-B1 | FARNESYL TRANSFERASE INHIBITING BENZOHETEROCYCLIC DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-24 | — | — | EP | claimed |
| US-7153958-B2 | Farnesyl transferase inhibiting benzoheterocyclic derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-26 | — | — | US | claimed |
| EP-1339709-B1 | FARNESYL TRANSFERASE INHIBITING BENZOHETEROCYCLIC DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-24 | — | — | EP | disclosed |
| US-7153958-B2 | Farnesyl transferase inhibiting benzoheterocyclic derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-26 | — | — | US | disclosed |