Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MARK3 | P27448 | 1/20 | 0.41 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 8/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | ITK | Q08881 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 3/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | ULK1 | O75385 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13901398 | 0.91 | TBK1 (0.43) | AURKAMARK3MARK4TBK1SYK | |
| SCHEMBL3863970 | 0.90 | TBK1 (0.51) | AURKAMARK3MARK4TBK1SYK | |
| SCHEMBL13901416 | 0.87 | EGFR (0.53) | AURKAMARK3MARK4TBK1SYK | |
| SCHEMBL13901339 | 0.87 | AURKA (0.42) | AURKAMARK3MARK4TBK1SYK | |
| SCHEMBL13901446 | 0.86 | EGFR (0.45) | AURKAMARK3MARK4TBK1SYK | |
| SCHEMBL13901400 | 0.86 | EGFR (0.43) | AURKAMARK3MARK4TBK1SYK | |
| SCHEMBL13901438 | 0.84 | PTK2 (0.45) | AURKAMARK3MARK4TBK1SYK | |
| SCHEMBL13901411 | 0.82 | SYK (0.37) | AURKASYKEGFRJAK3ITK | |
| SCHEMBL13901212 | 0.82 | TBK1 (0.60) | AURKAMARK3MARK4TBK1EGFR | |
| SCHEMBL13901504 | 0.82 | BRD4 (0.44) | AURKAMARK3MARK4TBK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504410-B2 | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |