Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 3/20 | 0.50 |
| ▸ | KHK | P50053 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1719788 | 0.99 | HPGD (0.51) | HPGDMAPK1PARP1KHKKDM4E | |
| SCHEMBL13901617 | 0.93 | HPGD (0.61) | HPGDMAPK1PARP1KHKKDM4E | |
| Hydrochloric Acid SCHEMBL1720180 | 0.92 | HPGD (0.60) | HPGDMAPK1PARP1KHKKDM4E | |
| SCHEMBL10227998 | 0.91 | PARP1 (0.55) | HPGDMAPK1PARP1KHKKDM4E | |
| SCHEMBL10228002 | 0.89 | PARP1 (0.54) | HPGDMAPK1PARP1KHKKDM4E | |
| Hydrochloric Acid SCHEMBL1719955 | 0.89 | PARP1 (0.54) | HPGDMAPK1PARP1KHKKDM4E | |
| Hydrochloric Acid SCHEMBL1720581 | 0.88 | PARP1 (0.53) | HPGDMAPK1PARP1KHKKDM4E | |
| SCHEMBL1720914 | 0.88 | KDM4E (0.56) | HPGDMAPK1PARP1KHKKDM4E | |
| Hydrochloric Acid SCHEMBL4069640 | 0.87 | KDM4E (0.56) | HPGDMAPK1PARP1KHKKDM4E | |
| SCHEMBL11286643 | 0.84 | HPGD (0.72) | HPGDMAPK1PARP1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501412-B2 | Isoquinoline compounds and medicinal use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-03-10 | — | — | US | disclosed |
| US-7501412-B2 | Isoquinoline compounds and medicinal use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-03-10 | — | — | US | disclosed |