Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 14/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13902798 | 0.86 | PTGER1 (0.50) | PTGER1CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL2954986 | 0.85 | PTGER1 (0.77) | PTGER1CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL2955012 | 0.82 | CYP1A2 (0.55) | PTGER1CYP1A2CYP2C9CYP2C19CYP3A4 | |
| Acetone SCHEMBL27709152 | 0.80 | CYP1A2 (0.52) | PTGER1CYP1A2CYP2C9CYP2C19TBXA2R | |
| SCHEMBL3212344 | 0.80 | PTGER1 (0.55) | PTGER1CYP1A2CYP2C9CYP2C19TBXA2R | |
| SCHEMBL2960944 | 0.79 | PTGER1 (0.77) | PTGER1CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL14397613 | 0.78 | CYP1A2 (0.52) | PTGER1CYP1A2CYP2C9CYP2C19TBXA2R | |
| SCHEMBL2962415 | 0.77 | PTGER1 (0.58) | PTGER1CYP1A2CYP2C9CYP2C19TBXA2R | |
| SCHEMBL2961468 | 0.77 | PTGER1 (0.77) | PTGER1CYP1A2CYP2C9CYP2C19TBXA2R | |
| SCHEMBL2949627 | 0.77 | PTGER1 (0.78) | PTGER1CYP1A2CYP2C9CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833795-B1 | PYRIDINE COMPOUNDS FOR THE TREATMENT OF PROSTAGLANDIN MEDIATED DISEASES | GLAXO GROUP LTD (GB) | 2009-03-04 | — | — | EP | disclosed |