Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | BMP1 | P13497 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 6/20 | 0.35 |
| ▸ | MMP9 | P14780 | 6/20 | 0.34 |
| ▸ | MMP3 | P08254 | 4/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | MMP8 | P22894 | 2/20 | 0.34 |
| ▸ | ENPEP | Q07075 | 3/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17450500 | 0.85 | ACE (0.41) | ACEBMP1KDM4EMAPTTHRB | |
| SCHEMBL13169333 | 0.83 | ACE (0.47) | ACEBMP1KDM4EMAPTTHRB | |
| SCHEMBL11111449 | 0.79 | — | — | |
| SCHEMBL10084643 | 0.79 | — | — | |
| SCHEMBL13163781 | 0.79 | — | — | |
| SCHEMBL1058215 | 0.77 | KDM4E (0.56) | ACEKDM4EMAPTTHRBALOX15 | |
| SCHEMBL1058214 | 0.77 | KDM4E (0.56) | ACEKDM4EMAPTTHRBALOX15 | |
| SCHEMBL19729234 | 0.77 | KDM4E (0.45) | ACEKDM4EMAPTTHRBALOX15 | |
| SCHEMBL17524631 | 0.77 | KDM4E (0.45) | ACEKDM4EMAPTTHRBALOX15 | |
| SCHEMBL25761663 | 0.77 | KDM4E (0.56) | ACEKDM4EMAPTTHRBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009027844-A2 | CRF CONJUGATES WITH EXTENDED HALF-LIVES | CELTIC PHARMA MANAGEMENT L.P. (BM) | 2009-03-05 | — | — | WO | disclosed |