Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13909025 | 0.87 | ALDH1A1 (0.49) | KDM4ESMN1; SMN2LMNAHTTGAA | |
| SCHEMBL15419642 | 0.76 | HSD17B10 (0.55) | KDM4EHSD17B10GAAMAPTCA1 | |
| SCHEMBL1397659 | 0.75 | KDM4E (0.63) | KDM4EHSD17B10SMN1; SMN2HTTRAB9A | |
| SCHEMBL2385151 | 0.75 | NPC1 (0.53) | KDM4EHSD17B10SMN1; SMN2LMNANPC1 | |
| SCHEMBL3808424 | 0.75 | GAA (0.62) | KDM4EHSD17B10GAAMAPTCA9 | |
| SCHEMBL15818589 | 0.74 | KDM4C (0.63) | KDM4E | |
| SCHEMBL15639856 | 0.73 | KDM4E (0.59) | KDM4EHSD17B10SMN1; SMN2RAB9AGAA | |
| SCHEMBL2475653 | 0.72 | KDM4E (0.58) | KDM4EHSD17B10SMN1; SMN2KCNH2CA1 | |
| SCHEMBL27327673 | 0.72 | HSD17B2 (0.50) | KDM4EHSD17B10NPC1RAB9AGAA | |
| SCHEMBL10820458 | 0.71 | KMT2A (0.60) | KDM4EHSD17B10SMN1; SMN2KCNH2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090060968-A1 | INHIBITORS OF PHOSPHATASES | SAUNDERS JEFFREY O | 2009-03-05 | — | — | US | disclosed |
| US-20090060968-A1 | INHIBITORS OF PHOSPHATASES | SAUNDERS JEFFREY O | 2009-03-05 | — | — | US | disclosed |
| US-7439249-B2 | Inhibitors of phosphatases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-10-21 | — | — | US | disclosed |
| US-7439249-B2 | Inhibitors of phosphatases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090060968-A1 | INHIBITORS OF PHOSPHATASES | PPM1G, PPM1A, PPM1F | KDM4E 1488/4885HSD17B10 2160/4885SMN1; SMN2 3825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.