SCHEMBL13909528

SCHEMBL13909528

Oc1cc2cccnc2s1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.56
ALDH1A1 P00352 3/20 0.44
MEN1 O00255 1/20 0.44
CASP1 P29466 1/20 0.44
CASP7 P55210 1/20 0.44
KMT2A Q03164 1/20 0.44
MMP2 P08253 2/20 0.42
TSHR P16473 2/20 0.42
CHRM1 P11229 1/20 0.42
COMT P21964 1/20 0.42
ADRA1A P35348 1/20 0.42
METAP2 P50579 1/20 0.42
METAP1 P53582 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
PDK1 Q15118 1/20 0.41
KDM4E B2RXH2 3/20 0.39
HTT P42858 2/20 0.39
GMNN O75496 1/20 0.39
LMNA P02545 1/20 0.39
TP53 P04637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12266347 0.77 CYP2A6 (0.55) CYP2A6ALDH1A1MEN1CASP1CASP7
SCHEMBL1107219 0.77 CYP2A6 (0.55) CYP2A6ALDH1A1MEN1CASP1KMT2A
SCHEMBL16023618 0.77 CYP2A6 (0.55) CYP2A6ALDH1A1MEN1CASP1CASP7
SCHEMBL25805441 0.77 CYP2A6 (0.55) CYP2A6ALDH1A1MEN1CASP1CASP7
SCHEMBL30060005 0.77 CYP2A6 (0.55) CYP2A6ALDH1A1MEN1CASP1CASP7
SCHEMBL24611854 0.77 CYP2A6 (0.55) CYP2A6ALDH1A1MEN1CASP1CASP7
SCHEMBL2919083 0.77 CYP2A6 (0.55) CYP2A6ALDH1A1MEN1KMT2AMMP2
SCHEMBL12434 0.77 CYP2A6 (0.55) CYP2A6ALDH1A1MMP2TSHRPDK1
SCHEMBL759925 0.76 MGLL (0.52) CYP2A6ALDH1A1MEN1CASP1CASP7
SCHEMBL2175943 0.76 CYP2A6 (0.63) CYP2A6ALDH1A1MEN1CASP1CASP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1317445-B1 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS ANORMED INC (CA) 2009-03-11 EP disclosed